230 
Caesar and Loretz suggest that for cinchona it is advisable to 
determine the moisture and the alkaloid content. For the latter they 
outline a method which includes a preliminary treatment with acidu- 
lated water, on a water bath : this aqueous solution is subsequently 
extracted with a mixture of ether and chloroform. — Geschafts-Ber., 
v. Caesar & Loretz, in Halle, a. S., 1906, pp. 92-95. 
Reichard. C., discusses the characteristic reactions of quinoidine 
and enumerates a number of reactions that he believes can be used 
for determining the identity of this mixture of alkaloidal sub- 
stances. — Pharm. Ztg., Berk, 1906, v. 51, p. 532. 
Spiegel, L., refers briefly to the work of Bertlielot and Gaudechon, 
Skraup and Egerer. Pecsics. Christensen, Zwerger. and Koenigs on 
the cinchona alkaloids. — Biochem. Centralbl.. Leipz.. 1906-7. v. 5, 
p. 102. 
Rabe. Paul, presents a contribution to our knowledge of the cin- 
chona alkaloids, dealing more particularly with the composition and 
properties of isonitrosoeinehotoxine. — Ann. d. Chem.. Leipz.. 1906, 
v. 350, pp. 180-203. 
Herder, M., discusses the relation of pure quinine and cinchonine 
with various reagents and the demonstration of these alkaloids in 
situ in various parts of the plant. — Arch. d. Pharm.. Berl., 1906, v. 
244. pp. 130, 131. 
Konigs ( Ber. d. dent. chem. Gesellsch.) discusses the constitution 
of the cinchona alkaloids in the relation of a piperidin base, which 
he terms chinuclidin with cincholoipon, a derivative of the cinchona 
alkaloids. — Pharm. Zentralh., 1906. v. 47, pp. 192. 193. 
An abstract (from Vidensk Selsk Skrift, 1906, p. 265, v. 7) dis- 
cusses the behavior of the cinchona alkaloids with chlorine and points 
out that cinchonine, cinchonidine. and quinine produce additional 
products with chlorine similar in nature to those produced with 
bromine. — Chem. Repert.. Cothen. 1906. v. 30. p. 231. 
Skey has pointed out that many alkaloids give precipitates with 
ammonium thiocyanate in the presence of a zinc or mercury salt. 
According to P. IV. Robertson (Proc. Chem. Soc.) the alkaloids 
most sensitive to this reaction are quinine and the other cinchona 
alkaloids. — Drug. Circ. & Chem. Gaz., X. Y.. 1906, v. 50. p. 47. 
The Ph. Brit. Committee of Reference in Pharmacy concludes that 
the assay process for tincture of cinchona requires revision, as does 
the assay process for liquid extract of cinchona. — Chem. & Drug., 
Lond., 1906. v. 69, p. 865. 
Puckner, TV. A., reviews some of the recent literature relating to 
the assay of cinchona. — Pharm. Rev., Milwaukee, 1906. v. 24. pp. 
234-236.' 
Francis, John M., believes that the U. S. P. VIII method for the 
assay of cinchona is possessed of no advantage over the one previously 
