233 
in g six varied from 3.76 to 4.86 per cent. Two samples of cinchona 
from Kamerun also fell below the required 5 per cent of total alka- 
loids. — Helfenberger Annalen, 1905, Berl., 1906, v. 18, pp. 117-120. 
Spindler reports finding four samples of cinchona with from 3.05 
to 4.7 per cent of alkaloids in place of the 5 per cent required. — 
Siidd. Apoth. Ztg., 1906, v. 46, p. 90. 
Evans Sons Lescher and Webb found a sample of cinchona bark 
which yielded 10.9 per cent of total alkaloids. — Analytical Notes for 
1906, 1907, p. 12. 
Weisz, Ernst, discusses the value of extract of cinchona of the Ph. 
Austr. VIII, and records a comparative study of some available 
commercial samples. He concludes that these samples are not par- 
ticularly creditable, and suggests that the pharmacist should prepare 
the extract himself. (From Ztschr. d. allg. osterr. A. V., 1906.) — 
Apoth. Ztg., Berl., 1906, v. 21, pp. 439, 440. 
Desmaisons suggests a formula for fluid extract of cinchona includ- 
ing dilute hydrochloric acid in the menstruum. The finished product 
has a specific gravity of 1.116 at 15° C., leaves a residue of 38.88 per 
cent at 100°, 18.88 per cent extractive, and 4.565 per cent alkaloids. — 
Bull, des sc. pharmacol., Par., 1906, v. 13 (Compt. rend, des soc. sav.), 
p. 201. 
Dreliere, Walter, outlines a method for preparing fluid extract 
of cinchona, discusses the content of alkaloids, and suggests a method 
of assay which is described. — ,T. de pharm. d’ Anvers, 1906, v. 62, pp. 
934-937. 
van der Wielen, P., points out that the formula for extract of cin- 
chona as proposed by Th. (in the Schweiz. Wchnschr. f. Chem. u. 
Pharm., 1906, v. 44, pp. 56, 57) does not produce a satisfactory prep- 
aration. He also points out that the preparation was originally pro- 
posed by de Vriji in 1891, and that an improved formula suggested 
by van der Wielen (Pharm. Weekblad) in 1903 was subsequently 
preferred to the formula by de Vriji which had been embodied in the 
Supplement to the Netherlands Pharmacopoeia. — Schweiz. Wchnschr. 
f. Chem. u. Pharm., 1906, v. 44, pp. 244-246. 
Dott, D. B., asserts that cinchona is much more readily extracted 
by 60 per cent spirit than by the official menstruum. In this case it 
is well to add 1 per cent hydrochloric acid with the first maceration, 
distill off the spirit and make up to the volume indicated by the alka- 
loidal assay, using one-tenth volume of glycerin and one-fifth volume 
of alcohol. — Yearbook of Pharmacy, 1906, p. 300. 
The Ph. Brit. Committee of Reference in Pharmacy report on 
liquid extract of cinchona says : “ Amend the assay process.” — Chem. 
& Drug., Lond., 1906, v. 69, p. 863. 
Weisz, Ernst, presents some observations on the several pharma- 
ceutical preparations of cinchona and outlines a method for determin- 
