239 
the bases as pseudotropin and ecgonin. — Biochem. Centralbl., Leipz., 
1906-7, v. 5, p. 909. 
He also discusses the a at ion of bromine on cocaine and points out 
that in the presence of hvdrobromic acid, in a solution of cocaine in 
carbon tetrachloride or water, yellow cr}- stals of a combination having 
the formula C 17 H 21 0 4 N.HBrBr 2 and insoluble in water are formed. — 
Ibicl., v. 5, p. 909. 
Spiegel, L., discusses the chemistry of cocaine and its decomposition 
products. — Ibid., v. 5, p. 159. 
Peichard, C., discusses the several reactions for cocaine and its 
differentiation from other alkaloids. — Pharm. Zentralh., 1906, v. 47. 
pp. 347-353, 925-927. 
He outlines a new reaction for cocaine; a color reaction produced 
by a mixture of a-nitroso j3-napthol, hydrochloric acid, and nickel 
sulphate. — Ibid., v. 47, p. 383. (See also Pharm. Ztg., Berl., 1906, 
v. 51, p. 168, 592.) 
Gehe & Co. discuss the market conditions prevailing for cocaine, 
the available supply, accession, the sale of crude cocaine in the Ham- 
burg market, and the prices prevailing for pure as Avell as for crude 
cocaine. — Handels-Ber., Gehe & Co., 1906, pp. 69, 70. 
Gonnermann, M., discusses the action of enzymes on cocaine. He 
finds that the liver of various animals, pancreatin, trypsin, and some 
of the vegetable ferments decompose cocaine more or less readily. — 
Apoth. Ztg., Berl., 1906, a*. 21. pp. 989-998. 
Gunther (Tierarztl. Centralbl., 1906) points out that with cocaine 
the pharmacologic action is evidently confined to the Avhole cocaine 
molecule, as neither, benzoylecgonin or eegoninmethylester are active. 
He also calls attention to the present practice of decomposing the 
amorphous alkaloids of coca to ecgonin and the synthesis of this 
to cocaine! — Pharm. Post, Wien, 1906, v. 39. p. 56. 
Post, E., presents a reAuew of the constitution of cocaine and the 
efforts made to produce synthetically substitutes for this article as 
a local anaesthetic. He points out that AAdiile at least some of the 
sjmthetic preparations have aclA T antages over cocaine, they are all 
less actAe as local anaesthetics, and concludes that their final disposi- 
tion must after all rest with the results obtained in active practice. — 
Therap. d. Gegenw., 1906, a\ 47, pp. 122-125, 
Gossling, W., discusses the chemistry and composition of cocaine 
and seA r eral of the newer anaesthetics. — Sudd. Apoth. Ztg., 1906, v. 46, 
p. 512. 
Maas, Th. A., discusses the use of cocaine and of other substances 
for rendering definite, circumscribed regions insensible to pain. He 
concludes that in face of the number of local anaesthetics before the 
