243 
Knorr, Ludwig, in collaboration with Heinrich Horlein discusses 
the conversion of thebaine into codeinone and codeine. — Ber. d. dent, 
cheni. Gesellscli., Berl., 1906, v. 39, pp. 1409-1414. 
The Ph. Brit. Committee of Reference in Pharmacy report on 
codeine says: 
In tlie color test, sodium arsenate should be substituted for potassium ferri- 
cyanide. Add to the tests “ codeine which has been dried at 100° C. melts at 
155° C.” — Chem. & Drug., Lond., 1906, v. 69, p. 863. 
Reichard, C., reviews the tests and reactions for codeine and the 
differentiation of this alkaloid from other substances. — Pharm. Zen- 
tralh., 1906, v. 47, pp. 727-733. 
Pschorr, R., (Chem. Ber., 1906, v. 39, pp. 3130-3139) discusses the 
production of halogen derivatives of codeine. — Biochem. Centralbl.. 
Leipz., 1906-7, v. 5, p. 762. 
Lowe, Clement B., asserts that codeine is usually considered as 
being one- fourth the strength of morphine and that the average dose 
of the former, one-half grain, does not compare well with the dose 
of morphine which is given as being one-fourth grain. — Proc. Penn- 
sylvania Pharm. Ass., 1906, p. 102. * 
Wokes has noticed that sirup of codeine does not keep well, and 
suggests that in place of simple sirup, as ordered in the Ph. Brit., IV, 
and in the N. F., sirup of tolu should be used in making it. — Pharm. 
J., Lond., 1906, v. 22, p. 175. 
Taylor, S., with others, finds that this sirup does not keep well ; 
he would suggest that the codeine phosphate be dissolved in the liquor 
tolu, and this added to the sirup, making a compound sirup of tolu 
and codeine. — Ibid., v. 23, p. 670. 
The Ph. Brit. Committee of Reference in Pharmacy suggests that 
the formula for sirup of codeine should be revised. — Chem. & Drug., 
Lond., 1906, v. 69, p. 865. 
Tinkham, H. C., is reported to have said at the meeting of the 
Vermont State Medical Society that codeine is the best form in which 
to administer opium after surgical operations to keep the patient 
quiet. Morphine is to be given if necessary. — J. Am. M. Ass., 1906, 
v. 47, p. 1677. 
COLCHICI COEMUS. 
Smith, F. A. Upshur, reviews the history of, and the literature 
relating to, the chemistry of colchicum; and presents a summary of 
the reported work on the colchicine content of the drug. — Brit. & 
Col. Drug., Lond., 1906, v. 49, pp. 274-276. 
Mittelbach, Mm., asks, Why recognize both the root and the seed; 
if one be stronger than the other, why not drop the weaker? — Proc. 
Missouri Pharm. Ass.. 1906. p. 41. 
Gordin. H. M.. for the assay of colchicum, advises the use of the 
shaking tube. In case of the conn, the colchicine before it is weighed 
