247 
Francis, John M.. asserts that 100 pounds of drug yields 30 pounds 
of pulp — 10.5 pounds of extract. If the seeds are extracted with ben- 
zin to remove the oil. dried, extracted with 75 per cent alcohol, the 
extract is almost as active as the U. S. P. product. — Proc. Am. Pharm. 
Ass., 1906, v. 54, p. 336. 
Evans Sons Lescher and Webb found the petroleum ether extract of 
two samples of colocynth pulp, freed from seeds, to be 0.2 per cent 
and 0.4 per cent, respectively. The results from powder were 0.7, 1.4, 
O. 3, and 9 per cent. They assert that they had previously noticed 
Spanish pulp, quite free from seeds, with as much as 14 per cent of 
ether extract. — Analytical Notes for 1906, 1907, p. 15. 
Patch, E. L., reports on two samples of colocynth pulp which 
yielded 49.6 and 46.5 per cent of extractive, respectively, to dilute 
alcohol. — Proc. Am. Pharm. Ass., 1906, v. 54, p. 336. 
MacCallum, John Bruce, includes colocynth in a study of the ac- 
tion of certain vegetable cathartics on the isolated center of a jelly- 
fish (Polyorchis) . — J. Biol. Chem., 1906-7, v. 2, p. 390. 
Chiron, Paul, (L’Art Med.) recommends colocynth in sciatica of 
the right side. — Abstr. Hahneman. Month., Phila., 1906, v. 41, p. 878. 
CONIUM. 
Henkel, Alice, mentions Conium maculatum L., commonly known 
as conium, poison hemlock, spotted parsley, and spotted cowbane, as 
naturalized from Europe; common in waste places, especially in the 
Eastern and Middle States. — Bui. Bur. Plant Ind., U. S. Dept. 
Agric., 1906, No. 89, v. 23. 
The Ph. Brit. Committee of Reference in Pharmacy report on 
conium fruit says : These preparations should be assayed. The U. S. 
P. minimum (0.5 per cent of coniine) is too low. — Chem. & Drug., 
Bond., 1906, v. 69, p. 863. 
Smith, F. A. Upshur, points out that the U. S. P. VIII age lim- 
itation of two years on conium is important and should be remem- 
bered also in connection with the preparations of conium. — Pharm. 
J., Lond., 1906, v. 22, p. 63. 
Gordin, H. M., reviews the progress made in the chemistry of 
coniine during the year 1905, and among other points outlines the two 
color reactions devised hy Reichard to distinguish coniine from nico- 
tine. — Pharm. Rev., Milwaukee, 1906, v. 24, p. 209. 
Spiegel, L., refers briefly to the work of Ahrens, Braun, Wills- 
tatter, Loffler, and Meyer on the conium alkaloids. — Biochem. Cen- 
tralbl., Leipz., 1906-7, v. 5, p. 99. 
Sc. reviews the work done on the conrposition of coniine and related 
bodies and the efforts made by Ladenburg to produce the alkaloid 
synthetically. — Pharm. Zentralh., 1906, v. 47, p. 807. 
