248 
Herder, M., discusses the reaction of coniine with various agents, 
and records some experiments that were made to demonstrate this ’ 
alkaloid in situ in conium seed. — Arch. d. Pharm., Berl., 1906, v. 
244, pp. 131, 132. 
Gabutti, Emilio, discusses the recognition of coniine and its differ- 
entiation from other liquid alkaloids. — Boll. chim. farm., Milan, 
1906, v. 45, pp. 289, 290. 
Gane, E. H., says conium will average 0.2 per cent coniine. — Proc. 
Am. Pharm. Ass., 1906, v. 54, p. 336. 
Lyons, A. B., asserts that conium deteriorates so rapidly that only 
the large manufacturers have opportunity to procure a prime article. 
The fluid extract is very little used, and hardly deserves a place in 
the pharmacopoeia. — Ibid., v. 54, p. 439. 
Gordin, H. M., considers the assay method very complicated; it 
will hardly give concordant results in the hands of different chem- 
ists. — Am. J. Pharm., Phila., 1906, v. 78, pp. 455^57. 
Lyons, A. B., reports that 5 out of 8 persons who had tried the 
assay process for conium thought the U. S. P. standard for the fluid 
extract satisfactory and readily maintained. — Proc. Am. Pharm. Ass., 
1906, v. 54, p. 437. 
Puckner, W. A., reviews some of the recent literature relating to 
the assay of conium, and points out that the retention of a little fat 
will cause an appreciable error in the final result. On the other hand, 
since the free alkaloid is volatile at ordinary temperature, its loss by 
evaporation is rather liable to occur in case of faulty procedure and 
cause low results. — Pharm. Rev., Milwaukee, 1906, v. 24, p. 267. 
Moerk, Frank X., points out that fluid extract of conium represents 
but 90 per cent of the active constituents of the drug in place of 100 
per cent as is generally supposed.— Proc. Pennsylvania Pharm. Ass., 
1906, p. 159. 
Webster, Herbert T., commends conium in the treatment of chronic 
diseases. * * * “ Those who devote themselves largely to acute 
practice will get little help from it." — Eclectic Med. J., Cincin., 1906, 
v. 66, pp. 255-260. 
McMillen says: 
The specific indication for conium by which I have selected it for use is ex- 
cessive motility. The patient is in constant motion ; when awake, often noisy, 
and destructive of clothing and furniture ; under acute maniacal excitement. — 
Ibid., p. 456. 
Fyfe, John William, says that conium was employed in acute dis- 
eases as a means of relieving pain, also to “ discuss scrofulous and 
cancerous tumors of the breasts,” both internally and locally.— Ibid., 
v. 66, p. 319. 
