256 
pharmacological references in addition to the details of his own 
researches. — Arch, internat. cle pharmacod. et de therap., Par., 1906, 
v. 16, pp. 34-356. (See also General Conclusions, Ibid., p. 449 ff.) 
Lewin discusses the apparent discrepancy in the maximum dose of 
diacetyl-morphine hydrochloride (heroin hydrochloride) as given in 
the several authoritative lists. He points out that heroin has been 
shown to be 33 per cent more poisonous than morphine and that the 
maximum daily dose is more than 100 per cent more poisonous than 
morphine. He also points out that many persons are particularly 
susceptible to the effects of heroin and that this effect should not be 
lost sight of. — Apoth. Ztg. Berl., 1906, v. 21, p. 502. 
DIGITALIS. 
Henkel, Alice, mentions Digitalis purpurea L., commonly known 
as digitalis, foxglove, fairy fingers, thimbles, and lady’s glove, as 
having been introduced from Europe as a garden plant, and now 
escaped from cultivation in parts of Oregon, Washington, and West 
Virginia, — Bui. Bur. Plant Ind., U. S. Dept. Agric., 1906, No. 89, 
p. 26. 
True, Rodney H, points out that the cultivator of digitalis must 
contend with the fact that the leaves should be gathered in the second 
year at the time of flowering, that they are distributed along the stem 
and must be gathered one by one, and that the plant occupies the 
ground for two years. — Oil, Paint, and Drug. Rep., 1906, v. TO, Oct. 
17, p. 37. 
Grier, J., suggests that the Pli. Brit, restrict the official digitalis to 
the English grown biennial leaves, not more than 1 year old. — Pharm. 
J., Lonch, 1906, v. 22, p. 238. 
The Ph. Brit. Committee of Reference in Pharmacy report on digi- 
talis leaves says : 
Chemical assay impossible, and physiological assay not feasible. Directions 
must be given for carefully drying and storing. Also ash limit and revised 
microscopical characters. — Chem. & Drug. Loud., 1906, v. 69, p. 863. 
Wang, E. (Festschr. f. O. Hammarstein) , points out that Norwe- 
gian digitalis leaves have an average value, rather than an abnor- 
mally high one as generally supposed. — Biocliem. Centrlbl. Leipz., 
1906-7, v. 5, p. 703. 
Bohny, Paul, (Inaug-Dissertation, Zurich, 1906) presents a com- 
prehensive description of the morphology and anatomy of the leaves 
of Digitalis purpurea L. and of the leaves used as adulterants of this 
drug. — Bot. Centralbl. Cassel, 1906, v. 102, p. 267. 
Wippern, Franz, asserts that it would be desirable for the pharma- 
copoeia to define more clearly how the leaves of digitalis are to be 
kept. He also points out that to avoid possible disappointment with 
