271 
Crawford, A. C., reviews in a very comprehensive way the litera- 
ture of the separation of the active principles, color tests, principal 
ph} T siological tests, and toxicity of the active principle of suprarenal 
gland. — Bull. Bur. Plant. Inch U. S. Dept. Agric., 1907, Xo. 112. 
Cameron, I. D., summarizes his work on the standardization of 
adrenalin preparations : (a) The colorimetric method is not reliable 
with weak or impure solutions. (b) The effect on the pupil of the 
frog’s eye gives uncertain results, (c) The determination of the 
minimum effective dose on the arterioles of the perfused frog is 
tedious and uncertain; on an average 0.1 per million produces an 
effect, (d) The determination of the minimum effective dose in 
causing a rise on the blood pressure of the atropinised rabbit yields 
satisfactory results, (e) Adrenalin, suprarenalin, and hemisine all 
give a precisely similar result, 0.0003 mg. per kilo of body weight, 
or 0.006 per million, of the rabbit’s blood, causing a distinct rise in 
the blood pressure in the rabbit, and 0.012 mg. per kilo of body 
weight, or 0.24 per million, of the blood causing a rise in the cat. (/) 
The most satisfactory method is the determination of the dose just 
sufficient to antagonize 0.6 mg gr.) of nitroglycerin. Of ad- 
renalin, 0.0075 mg. is sufficient. — Reprint from Proc. Roy. Soc. Edin- 
burgh, 1906, v. 26, pt. 3, pp. 157-171. 
Hunt, Reid, compares the physiologic activity of several commer- 
cial suprarenal preparations, and finds some specimens to be five times 
as active as others. — J. Am. M. Ass., 1906, v. 47, pp. 790—792. 
Sollmann and Brown compare the physiologic activity of several 
commercial suprarenal preparations and find considerable variation 
in their jffiysiologic activity and their keeping qualities. — Ibid ., v. 47, 
p. 792. 
Friedman, E., ( Hof meister’s Beitr. Bel. 8, pp. 95-120) discusses 
the formula of adrenalin and some of its derivatives and suggests 
that the origin of adrenalin, in the organism, is probably albumin. — 
Abstr. in Biochem. Centralbl., Leipz., 1906-7, v. 5, p. 274. 
Hall, Walter L., discusses the chemistry of adrenalin and its 
formation in the organism. — Beitr. z. chem. Physiol, u. Path. 
Brnschwg., 1906, v. 8, pp. 278-280. 
Moller, S., completes an exhaustive study of epinephrine with an 
extensive bibliographic list. — Tlierap. Monatsh., Berl., 1906, v. 20, 
pp. 25-39, 85-99. 
Elliott and Durham report experiments made to determine whether 
the continued administration of adrenalin would tend to produce 
antibodies in the animal organism. (J. of Physiol., 1906, v. 34, 
p. 490). — Biochem. Centralbl., Leipz., 1906-7, v. 5, p. 908. 
D’Amato and Fagella report a study on the nature and meaning 
of the aortic lesions caused by extracts of the suprarenal gland. — 
