306 
guaiacum in the treatment of gout. — J. Am. M. Ass., 1906, v. 47, 
p. 312. 
GUAR AN A. 
Puckner, W. A., reviews the literature relating to the assay of 
caffeine-bearing drugs, and points out that the addition of ether to 
the residue remaining after the final evaporation of the chloroform 
is unnecessary. Plis experiments appear to indicate that caffeine 
does not become anhydrous when dried at the temperature of boiling 
water, even if continued for days. — Pharm. Rev., Milwaukee, 1906, 
v. 24, pp. 236-237. 
Vanderkleed, C. E., is quoted as asserting that it is easy to obtain 
guarana assaying above the U. S. P. standard, but the drug is diffi- 
cult to exhaust. — Proc. Am. Pharm. Ass., 1906, v. 54, p. 439. 
Francis, John M., has examined many samples, representing sev- 
eral thousand pounds, and has not yet found one to assay below 4 per 
cent of caffeine and associated principles. — Bull. Pharm., Detroit, 
1906, v. 20, p. 54. 
Patch, E. L., reports on three samples of guarana which contained 
4.32 and 4.9 per cent of alkaloid, respectively. — Proc. Am. Pharm. ' 
Ass., 1906, v. 54, p. 337. 
Lyons, A. B., reports that eight of the twelve replies received indi- 
cated that the U. S. P. standard for fluid extract of guarana is satis- 
factory and readily maintained. — Proc. Am. Pharm. Ass., 1906, v. 54, 
p. 437. 
HAMAMELIS. 
Henkel, Alice, mentions Hamamelis virginiana L., commonly called 
hamamelis, witch-hazel, winterbloom, and snapping hazel, as being 
found in damp woods from New Brunswick to Minnesota, south to 
Florida and Texas. — Bull. Bur. Plant. Ind., U. S. Dept. Agric., 
1906, No. 88, p. 35. 
Schneider, Albert, asserts that Hamamelis virginiana L., is a very 
popular Indian remedy for bruises, sores, cuts, and other injuries. — 
Merck's Report, N. Y., 1906, v. 15, pp. 95-96. 
The Ph. Brit. Committee of Reference in Pharmacy report that for 
hamamelis bark and leaves an ash limit is not necessary. — Chem. 
& Drug., Bond., 1906, v. 69, p. 863. 
Mittlebach, Wm., asks why both the leaves and the bark were recog- 
nized ; why not recognize that part of the plant which is strongest in 
medicinal properties ? 
Hemm, Francis, and Hamill, E. C., note that different preparations 
are sometimes made from different parts of the drug. — Proc. Missouri 
Pharm. Ass., 1906, p. 38. 
Mundy discusses the specific indications for u Hamamelis Yir- 
ginius " [sic] ; the three conditions in which he finds it especially 
