323 
Vanderkleed, Charles E., reports the assay of 15 lots of hyoscya- 
mus which averaged 0.111 per cent. Two samples assayed below 
the required 0.08 per cent. — Proc. Pennsylvania Pharm. Ass., 1906, 
p. 123. 
Smith, Kline & French Co. report on the examination of one 
sample of hyoscyamus leaves which contained 0.11 per cent mydriatic 
alkaloids. — Lab. Rep. S. K. & F., 1906, p. IT. 
Moerk, Frank X., points out that fluid extract of hyoscyamus 
represents but 93.75 per cent of the active ingredients in the drug. 
The tincture represents 9 per cent of the contained alkaloids and the 
extract is 3. 75 times the strength of the drug itself. — Proc. Penn- 
sylvania Pharm. Ass., 1906, p. 159. 
Lyons, A. B., reports that 8 of the 12 replies received were in favor 
of, and not any objected to, the original U. S. P. standard of 0.075 
per cent of alkaloids in fluid extract of hyoscyamus. — Proc. Am. 
Pharm. Ass., 1906, v. 54, p. 437. 
Francis, John M., thinks the adoption of the low standard of 0.075 
per cent of alkaloids for fluid extract of hyoscyamus as illogical as 
the higher standard of 0.5 per cent of mydriatic alkaloids for fluid 
extracts of belladonna root [later 0.4 per cent]. Judging from ten 
years’ records, he thinks the standard of 0.1 per cent of mydriatic 
alkaloids wholly practicable and nothing more than the fair average 
for commercial drug of fair quality. He thinks the abolition of the 
j ;4 double menstruum ” a matter of congratulation. — Bull. Pharm., 
Detroit, 1906, v. 20, p. 10. 
See Gordin's comment under Belladonna Radix. 
Dieterich, Karl, reports on a number of samples of extract of 
hvoscvamus of the Ph. Germ. IY, Ph. Austr. YII, and Ph. Austr. 
YIII. The moisture content varied from 17.51 to 25.57 and the ash 
from 10.91 to 23.72 per cent. The alkaloid content varied from 0.170 
to 1.11 per cent. — Helfenberger Annalen, 1905, 1906, v. 18, p. 161-162. 
Philipp Roder, Wien, reports examining four samples of extract of 
hyoscyamus, which varied from 0.227 to 0.460 per cent of alkaloids. — 
Pharm. Post, Wien, 1906, v. 39, p. 263. 
Mundy quotes Bartholow, Ellingwood, and Hare and summarizes 
thus: Specific indications, nervous irritability, with unrest and in- 
somnia; terror, restlessness in sleep, delirium of a noisy character; 
delusions and hallucinations, agitation and the insomnia of debility 
and exhaustion. Dose, gtt. 2 to 10; hvoscyamine, one-sixtieth to 
one-fiftieth of a grain; hvoscine, one-ninetieth to one-eightieth of a 
grain. — Eclectic Med. J., Cincin., 1906, v. 66, p. 206. 
INFUSA. 
Corcoran and Griffiths protest against the making of certain infu- 
sions from fluid extracts. 
