372 
Gane, E. H., found one sample of nux vomica to assay 1.47 per 
cent of strychnine and asserts that much of the available nux vomica 
is above the U. S. P. VIII standard. — Proc. Am. Pharm. Ass., 1906, 
v. 54, p. 340. 
Patch, E. L., found nux vomica to assay 1.27 and 1.22 per cent of 
strychnine and 2.67 and 3.4 per cent of total alkaloids, respectively. — 
Ibid, v. 54, p. 340. 
Vanderkleed, Charles E., examined seven lots of powdered nux 
vomica which assayed an average of 1.1 per cent of strychnine. Only 
one sample of the ground drug exceeded the required 1.25 per cent. — 
Proc. Pennsylvania Pharm. Ass., 1906, p. 123. 
Ohliger, Willard, finds nux vomica usually below standard in 
strychnine content. — Proc. Michigan Pharm. Ass., 1906, p. 48. 
Smith. Kline & French Co. report on the examination of two sam- 
ples of nux vomica. They contained 2.46 per cent and 2.4 per cent of 
total alkaloids, respectively. — Lab. Eep., S. K. & F., 1906, p. 18. 
Philipp Koder, Wien, examined five samples of nux vomica and 
found from 1.34 to 2.93 per cent of ash, from 1.03 to 2.82 per cent of 
alkaloid, and from 9.43 to 13.94 per cent of extract soluble in 70 per 
cent of alcohol. The Ph. Austr. VIII requires 2.5 per cent of total 
alkaloid, 12 per cent of extract, and not exceeding 3 per cent of ash. — 
Pharm. Post, Wien, 1906, v. 39, p. 296. 
Moerk, Frank X., points out that the extract of nux vomica is four 
times the strength of the drug and that the fluid extract represents 
only 80 per cent of the active constituents of nux vomica in place of 
100 per cent or c. c. for gramme, as is generally supposed. Tincture 
of nux vomica, made from the extract, contains alkaloid to the extent 
of 8 per cent of the drug. — Proc. Pennsylvania Pharm. Ass., 1906, 
p. 159. 
Francis, John M., criticizes the pharmacopceial methods for prepa- 
rations of nux vomica and has often wondered how they had been 
retained through the various revisions. — Proc. Am. Pharm. Ass., 1906, 
v. 54, p. 430. 
Beysen, Kurt, suggests that the Ph. Germ, require that the partially 
concentrated extractive of nux vomica be allowed to stand for several 
days, filtered, and then freed from oil by means of petroleum ether. 
The resulting material is then evaporated to dryness. — Ber. d. pharm. 
Gesellsch., Berl., 1906, v. 16, p. 328. 
Taylor, S., mentions the necessity of freeing all preparations of 
nux vomica from fat, and recommends the use of paraffin. — Pharm. 
J., Fond., 1906, v. 23, p. 669. 
Alcock, F. H., in discussing a paper by Farr and Wright, pro- 
posed carbon tetrachloride as a solvent for the fat in nux vomica. 
This solvent, he asserts, is cheap, non-inflammable, very volatile, and 
