450 
Boch. M., (Semaine Med.) elaborates on a suggestion, made by 
Yvon, to mask the taste of quinine by mixing the drug with a fatty 
substance and proposes boluses of quinine with oil of theobroma. 
The bolus is to be taken with hot milk. — Drug. Circ. & Chem. Gaz.. 
X. Y., 1906, v. 50, p. 395. 
Laqueur, Ernst, presents a study of the action of quinine on fer- 
ments with a particular consideration of its probable effect on me- 
tabolism. — Arch. f. exper. Path. u. Pharmakol., 1906, y. 55, pp. 
240-261. 
Bodriguez Carracido. Jose. (Bev. de la B. Acad, de Ciencias, v. 3. 
pp. 141-148 ; An. de la Soc. esp. de fis. y quim. Madrid. 1905, v. 3, pp. 
276-283) discusses the action of quinine and pilocarpine on oxid- 
ases. — Abstr. in Biochem. Centralbl., Leipz., 1906-7, v. 5, p. 130. 
Schmitz, Bichard, discusses the elimination of quinine in the urine, 
the form in which it is eliminated, the quantity eliminated, the elimi- 
nation following subcutaneous administration, the elimination of 
quinine in the foeces, and finally presents his conclusions. — Arch, 
exper. Path. u. Pharmakol., 1906, v. 56, pp. 301-313. 
Morgenbesser, H., experimenting on himself, found that quinine 
caused a decreased excretion of nitrogen, confirming the more gen- 
erally held opinion that it decreases the metabolism. — X. York M. J., 
1906^ v. 83, p. 762. 
Brem, Walter V., states that the treatment of malarial haemoglo- 
binuria may be summed up in the word quinine. The 1.107 malarial 
patients received as routine treatment from 20 to 40 grains of quinine 
daily. — J. Am. M. Ass., 1906, v. 47, pp. 1992-1997. 
QUININE HYDROCHLORIDUM. 
Carrette states that the neutral quinine chlorhydrate when crystal- 
lized in water contains 24 molecules of water of crystallization, but 
when crystallized in alcohol its composition is different, and so the 
quantity of quinine in the compound varies. — J. de pharm. et de 
ehim. Par., 1906. v. 23. p. 134. 
Lebeaupin. in a report to the therapeutic society, urges the neces- 
sity for the use of soluble neutral salts of quinine for hypodermic 
injections, the avoidance of any fault of asepsis and injection deep 
into the muscle. — J. de pharm. et de chim. Par.. 1906, v. 24. pp. 42, 43. 
Brem, Walter Y.. reports that he found the intramuscular injection 
of quinine bihydrochloride caused less irritation than did that of the 
bimuriate and urea, but that neither caused great discomfort. — 
J. Am. M. Ass., 1906, v. 47, p. 1904. 
Guigues, P.. following up his studies of the incompatibility of 
quinine and acetate of ammonia, has produced neutral and basic 
formiates of quinine and describes their characters. — J. de pharm. 
et de chim. Par., 1906, v. 24, p 301. 
