452 
podophyllin is a matter requiring further consideration. The com- 
mittee does not know of a satisfactory test to distinguish the one 
variety from the other. — Chem. & Drug., Lond., 1906, v. 69, p. 864. 
Dott. D. B.. discusses the difference in the behavior of the resinoid 
from Podophyllum emodi from that obtained from Podophyllum 
peltatum when they are dissolved in water of ammonia. — Pharm. J., 
Lond., 1906, v. 23, p. 431. 
Lenton. Walter H., welcomes the above note and savs that the ex- 
i J «/ 
animation of a large number of samples, representing many thousand 
pounds of root, leads him to suggest that a 10 per cent limit of insol- 
uble matter errs well on the side of leniency. — Ibid., v. 23, p. 478. 
Martin, G., asserts that podophyllin may be grossly adulterated 
and still meet the U. S. P. tests. The yellow variety is precipitated 
by alum. The solubilities do not conform to the U. S. P., and it 
contains less than 1 per cent of ash. The brown variety is precipi- 
tated with hydrochloric acid and is nearly of equal merit with the 
U. S. P. — Proc. Am. Pharm. Ass., 1906, v. 54, p. 344. 
Patch. E. L.. reports examining a number of samples of podophyl- 
lin which varied from being completely soluble in alcohol to a residue 
of from 1 to 5.6 per cent insoluble in alcohol. — Ibid., v. 54, p. 344. 
Yanderkleed, Charles E., finds that much of the resin of podophyl- 
lin on the market tests only 90 to 95 per cent alcohol soluble. One 
manufacturer reported inability to make resin of podophyllin above 
95 per cent alcohol soluble. — Proc. Pennsylvania Pharm. Ass., 1906. 
p. 123. 
French. Harry B., asserts that much of the resin of podophyllum, 
or “ podophyllin " as it is popularly called, is made with acetone and 
not with alcohol, as the pharmacopoeia directs. He points out that 
though acetone does generally have the same solvent properties as 
alcohol, resin of podophyllin being a mixture of different proximate 
principles, it remains to be proven that the acetone product is as active 
physiologically as the alcohol product. — Drug. Circ. & Chem. Gaz., 
K Y., 1906, v. 50, p. 302. 
An unsigned report gives details relating to a fatal case of poison- 
ing from 18 grains of podophyllin. — Australas. J. Pharm., Mel- 
bourne, 1906, v. 21, pp. 254, 255. 
In the case of poisoning of a workman, a coroner's jury rendered a 
verdict of death from podophyllin poison inadvertently taken. — 
Pharm. J.. Lond., 1906. v. 23, p. 311. 
Leming, 'William, (Modern Eclecticism) recommends podophyllin 
where there is general atonicitv. with glandular sluggishness and 
dry, hard stools, the tongue full, generally pale and coated at the 
base. — Abstr. Eclectic Med. J.. Cinein.. 1906, v. 66, p. 441. 
Watkins says that podophyllin is adapted to that uncertain condi- 
tion called " billiousness,'* which, in fact, is ptomaine infection from a 
