470 
Vaughan, Ruediger, Smith, and Rosenau discussed the paper of 
Rosenau and Anderson just referred to. — J. Am. M. Ass., 1900, v. 47, 
pp. 1009, 1010. 
Merck’s Ann. Report, 1906, Darmstadt, 1907, v. 20, pp. 221-229, 
gives a number of references on the subject of curative sera. Addi- 
tional references will be found in the Index Medicus and the J. Am. 
M. Ass. 
SERUM ANTIDIPHTHERICUM. 
The Pli. Belg., Ill, includes serum antidiphthericum in the liquid 
form, while the Ph. Japon., Ill, includes both the liquid as well as 
the dried. 
Layson, L. C., discusses the antitoxic depreciation in antidiph- 
theritic serum, records his own experiments, method of testing, and 
the results. — Therapist, Lond., 1906, v. 16, pp. 5-8. 
Marx, E., presents some information on the permanence of anti- 
diphtheric serum and records results obtained with serum upward 
of 5 years old. — Xew Idea. Detroit, 1906, v. 28. pp. 87-89. (From the 
Festschrift issued in honor of Robert Koch's sixtieth birthday.) 
Weill-Halle and Lemaire point out that antiserum, a serum ob- 
tained from a rabbit immunized to horse serum, will cause a copious 
precipitation in an antidiphtheric serum obtained from horses, and 
that this precipitate will include a varying amount of the antitoxin 
which may be washed out with water. (Soc. biol., 1906, v. 61, p. 
407.) — Biochem. Centralbl., Leipz., 1906-7, v. 5, p. 898. 
An editorial calls attention to the advantages of the Gibson method 
of preparing antitoxin. — X. York M. J., 1906, v. 83, p. 92. 
Park and Throne think it safe to conclude from the results in 
100 cases that the removal of a part of the nonantitoxic globulins 
and the albumins from the serum by the Gibson method has elimi- 
nated much of the deleterious matter from the serum, so that con- 
stitutional disturbances are less likely to occur. — J. Am. M. Ass., 
1906, v. 47, p. 1854; Am. J. M. Sc., Phila., 1906, v. 132, pp. 686-692. 
Rahn, A., discusses the general question of diphtheria serum 
therapy statistics and the precautions to be observed in compiling 
them. — Therap. Monatsh., Berl., 1906, v. 20. pp. 78-82. 
Cornell, Maker S.. reports 600 cases of diphtheria and states that 
antitoxin is harmless in the largest doses; that early dosage is essen- 
trial to success, but that many physicians still do not -believe in the use 
of antitoxin. — X. York M. J., 1906, v. 84, p. 835. 
Pilcher, A. M., tabulates his cases of diphtheria for some years 
and states that he has the greatest confidence in the administration 
of the antidiphtherial serum by the mouth. — Brit. M. J., Lond., 1906, 
v. 1, p. 379. 
Rhodes, T. Basil, discusses the treatment of diphtheria and states 
that recovery usually follows the use of 4,000 to 6,000 units of anti- 
