471 
toxin on the third clay, and the physician would do well to admin- 
ister antitoxin when diphtheria is only suspected. — Ibid., v. 1, p. 376. 
Rolleston, J. P.. calls attention to the tonsilitis in convalescence 
from diphtheria and states that the chances of its being nonspecific 
are such that it should be dealt with locally first, owing to the severe 
manifestations which may follow fresh injections of serum. — Ibid ., 
v. 1, p. 1152. 
Keilly, T. F., calls attention to the use of large doses of diphtheria 
antitoxin and to the fact that it is useful against post-diphtheritic 
paralysis. — J. Am. M. Ass., 1906, v. 47, p. 649. 
Bracken, H. M., points out that the position of antidiphtlieric 
serum, in the prevention of diphtheria, is as nothing compared with 
vaccination in the prevention of smallpox; for the immunity con- 
ferred by antitoxin is of but short duration — rarely more than a 
month. The chief and great value of antitoxin is its curative rather 
than its preventive influence. — Trans. Am. Inst. Homoeop.. 1906, 62d 
sess., v. 1, p. 634. 
Anderson, John F., discusses maternal transmission of immunity 
to diphtheria toxin and hypersusceptibility to horse serum in the 
same animal. — Bull. Hyo\ Lab., U. S. P. H. and M. H. S., 1906, Xo. 
30, p. 19. 
Bosenau and Anderson report on a stomach lesion in guinea pigs 
caused by diphtheria toxin, and its bearing upon experimental gas- 
tric ulcer. — Bull. Hyg. Lab., U. S. P. H. and M. H. S., 1906, Xo. 32, 
pp. 10 with 11 figures. 
Additional references to the production and the uses of antidiph- 
theritic serum will be found in the Index Medicus and the J. 
Am. M. Ass. 
SERUM ANTITETANICUM. 
The Ph. Belg. Ill includes a description for the liquid antitetanic 
serum, while the Ph. Japon. Ill includes both the liquid as well as 
the dried. 
Waters, C. H., discusses the question of serum treatment in tetanus 
and the various problems that are involved; he concludes that anti- 
toxin serum is the natural and the best means of combating tetanus 
and that the essential factors in success are early use and careful tech- 
nique. — Therapist, Lond., 1906, v. 16, pp. 28, 29. 
The same author presents some additional notes on the therapeutic 
value of antitetanic serum and points out that many lives might be 
preserved if the prophylactic use of this antiserum was more gen- 
eral. — Ibid., pp. 109, 110. 
Dewey, E. L., reports a case of tetanus neonatorum treated with 
antitetanic serum and with chloral and potassium bromide with recov- 
ery. — J. Am. M. Ass., 1906, v. 47, p. 583. 
