483 
Patch, E. L., points out that the compound spirit of ether that is 
I marketed by many of our wholesale manufacturing chemists as U. S. 
P. does not bear any resemblance to the official product. It is sold 
at a price that will not pay for the ethereal oil alone. — Proc. Am. 
( Pharm. Ass., 1906, v. 54, p. 341. 
SPIRITUS JETHERIS COMPOSITUS. 
Francis, John M., notes the great improvement in the process of 
manufacture and the changes in the detail of the assay; other pro- 
cesses he considers tedious. — Bull. Pharm., Detroit, 1906, v. 20, p. 186. 
Wilson, J. Beetham, presents observations on the Ph. Brit, method 
for preparing spirit of nitrous ether and suggests that the distilla- 
tion may be safely hastened by using a higher temperature toward 
the end of the process. — Pharm. J., Bond., 1906, v. 22, p. 523. 
Vanderkleed, Charles E., discusses the preparing of spirit of nitrous 
ether from concentrated nitrous ether and points out several precau- 
tions that should be taken to prevent loss by evaporation. The re- 
sulting liquid should be assayed to insure its conforming to the 
requirement of the U. S. P. Outlines a method of assay without a 
nitrometer. — Proc. Pennsylvania Pharm. Ass., 1906, p. 132. 
Gane, E. H., reports on concentrated nitrous ether which assayed 
60.5 per cent in place of 88 per cent as claimed. — Proc. Am. Pharm. 
Ass., 1906, v. 54, p. 340. 
Sayre, L. E., reports that two samples of concentrated nitrous 
ether, when diluted as directed, yielded a spirit which contained 3 
and 3.63 per cent of ethyl nitrite, respectively. — Bull. Kansas Bd. 
Health, 1906, v. 2, p. 175. 
Evans, John, comments on the necessity for frequent examination 
of this preparation and on the rarity of the nitrometer in the equip- 
i ment of the pharmacy. When deteriorated it should promptly be 
replaced. — Apothecary, Boston, 1906, v. 18, p. 906. 
I Wiebelitz, H., in discussing the tests of the Ph. Germ, for spirit 
of nitrous ether suggests that the spirit be diluted with water, in 
making the determination of acid content, and that the titration be 
with one tenth normal solution of potassium hydroxide. — Pharm. 
Ztg., Berl., 1906, v. 51, p. 1004. 
Taylor, S., notes that this preparation has had some attention paid 
to it by Gilmour and Farrand Wright, but mainly with reference to 
its preservation. The general use of amber-colored glass lias lately 
been advocated, especially for the many preparations which are acted 
upon by light. — Pharm. J., Bond., 1906, v. 23, p. 670. 
Furbush, Willis St. B., discusses the history, tests and assay, de- 
composition, and commercial quality of nitrous ether. Only 1 of 
22 samples contained 4 per cent ethyl nitrite, and it was strongly 
