THE OXIDASES AND OTHER OXYGEN-CATALYSTS CON- 
CERNED IN BIOLOGICAL OXIDATIONS.” 
By Joseph H. Kastle, 
Chief, Division of Chemistry, Hygienic Laboratory, XJ. S. Public Health and Marine- 
Hospital Service. 
INTRODUCTION. 
During the past eight years I have devoted a considerable part of 
m} T time to a study of the oxidases and of certain phases of biological 
oxidation, with the result that I have come to appreciate as never 
before the need of a somewhat more comprehensive and complete 
treatment of this subject than is ordinarily to be found in most trea- 
tises on fermentation. Furthermore, a study of the earlier literature 
of the subject has revealed certain rather curious mistakes, which 
probably found their way into the literature originally as the result 
of typographical errors, but which pervade the whole subject with an 
annoying persistency. During the past four j^ears, as the result of 
easy access to the departmental libraries in this city, I have had 
unusual facilities for familiarizing myself with the literature of this 
subject, and it was partly with the view of giving to other workers in 
this field the benefits of my opportunities along this line, that this 
monograph has been written. No special claims are made for origi- 
nality either in the mode of treatment of the subject, or in some cases 
even with regard to phraseology, my only object being to present the- 
subject as accurately and comprehensively as possible within the time 
at my disposal. To this end I have made free use of such treatises 
on fermentation as ‘‘The soluble ferments and fermentation," by 
J. Reynolds Green (Cambridge Natural Science Manuals, London, 
1899); ‘‘Die Fermente und ihre TCirkungen," by Carl Oppenheimer, 
(Leipzig, 1900); “Traite de Microbiologie/' by E. Duclaux (Paris, 
1898); “Biochemie der Pflanzen," by Fred. Czapek (Jena, 1905); 
‘‘Theorie der Fermentwirkungen/’ by Moritz Traube (Berlin, 1858); 
‘‘Les Enzymes et leurs Applications," by Effront (translation by 
Prescott, New York, 1902); ‘“Recent advances in physiology and 
biochemistry/ 7 by Leonard Hill and others (London, 1906); ‘“Das 
Sauerstoff-Bedurfniss des Organismus," by Paul Ehrlich (Berlin, 
1885); ‘“Les Oxydations de l'Organisme," by E. Enriquez and J.-A. 
Sicard (Paris, 1902); ‘“Die Bedeutung der Katalyse fur die Medicin,” 
by H. Schade (Kiel, 1907) ; and “Kritische Studien uber die Yorgange 
“Manuscript submitted for publication October 12, 1909. 
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