The Morphology of Functional Activity in the Ganglion Gells etc. 523 
activity with its progressive hyperchromatism is accompanied by an 
increase in size of cell and nucleus in the same proportion (Text Fig. 5, 
Stages 1 to 2). Nor is this increase inconsiderable as may be üliistrated 
by the fifty per cent increase over the normal size that took place in 
Text Figure 5. 
the human case. Up to a certain point of activity then the nucleus- 
plasma relation is unchanged. Whether or not this represents the strictly 
normal limits of functional activity, it affords a sharp anatomical de- 
limitation. 
It is true that some of these initial variations in the size of ceUs pro- 
bably represent variations in the size of resting types rather than a state 
