526 
David H. Dolley 
Hodge type had to be renoimced as a result of tlie measurements. It 
does exist definitely, thougli it is not so pronounced. The shrinkage of 
the nucleus, always the predoniinant featiire, is tbere if that of the cell 
body is not, and at the same relative place, so that the very exact identity 
of the crayfish nucleus-plasma curve with that of the Piu'kinje cell is 
inaintained to this point. 
In the Purkinje cell, foUowing this mmünum of shrinkage, there 
begins toward the latter part of this same stage the secondary enlaxgement 
of the cell which continues to the end of the process (Text Fig. 5, Stage 5"). 
The first indication of it is the edema of the nucleus. So much more 
rapidly and intensely does this proceed in the nucleus than in the cell 
body that in the next stage the nucleus-plasma relation becomes shifted 
actuaUy in favor of the nucleus. As may be seen in the cm've from man 
(Text Fig. 5), this Stage 6 in the lower curve falls well below the base 
line. After this stage, the enlargement of the nucleus proceeds more 
slowly, while on the contrary the ratio of enlargement of the cytoplasm 
approaches, passes and continues to exceed that of the nucleus. Con- 
sequently, the relation as illustrated by the lower curve becomes pro- 
gressively more in favor of the cytoplasm from Stage 6 to the end. 
This general trend is repeated by the curves from the crayfish. The 
nucleus, following the last stage of nucleai' shrinkage, takes on a more 
rapid access of size than the ceU body. More commonly the indmdual 
sizes of the nuclei and hence the averages are noticeably increased. Con- 
sequently, the nucleus catches up with the ceU body as is shown by the 
smaller figures for the nucleus-plasma coefficients and the disproportion 
which existed is reduced. It is niost striking in all the cnrves that while 
the rise of the nuclens-plasma curve to this maximum tends to be abrupt, 
its decline is gradual, taldng place through several stages. The fall of 
the curve is so uniform in its occurrence and so distinct as compared 
with later variations that it must be homologous with that for the Pur- 
kinje cell and have the same significance. 
In one pai'ticular the respective courses of the Purkinje cell and 
the crayfish ceU ai’e not identical. In the Purkinje ceU it is apparent 
as well as substantiated by measurement that the edema begins in the 
nucleus. Mliile it makes itself evident from measurement in the cray- 
fish nucleus at the same point, as just stated, it is to be noted that it 
usually appears in the cytoplasm earlier, even before the shrinkage occurs. 
The writer is inclined to bclieve that this difference is more apparent 
than real, for increased fluid is certainly passing through the cell body of the 
Purkinje cell, even if it is not so clearly demonstrable as in the nucleus. 
