The Morphology of Functional Activity in tlie Ganglion Gells etc. 539 
(listinguished from the preceding stage whicli may entirely lack any 
extra-nuclear chromatin and which iiivariably averages smallcr in sizc 
and lower in its nucleus-plasma coefficient. Here it is preeminently in 
the process that the purpose of the functional hypertrophy is niade mani- 
fest. The three go together, the enlargement of the cell, the enlargement 
of the nucleus and the renewal of chromatin. If the nucleus were not 
so intimately concerned, why should it not only enlarge but initiate the 
enlai'gement? In short, as discussion would be largely a repetition, on 
the basis of purpose there seems no other probable correlation. 
FoUowing the process to the end, as a result of the increasing de- 
mand on the part of the cytoplasm, depending on the progressive dimi- 
nution of nuclear actmty, the nucleus-plasma relation comes to be dis- 
turbed in favor of the cytoplasm. With complete failme of the nucleus, 
the inevitable end is its deckromatinization, the final response to the 
cytoplasmic demand. With the disappearance of every vestige of basic 
chromatin, exhaustion is reached. But it is the exhaustion of chromatin 
only, as the essential substance in whose elaboration materials are con- 
sumed. The final proof that the extra-nuclear chromatin is the purpose- 
ful product of intraceUular coordination, the thing to whose formation 
both the plasma and the nucleus integrale on Stimulation, and as such, 
the source of energy, is to be found in its gradual restoration after rest 
along with recedence of the cell until the resting type is again reached 
(1911a). How completely the cell of Cambarus con'esponds in its ap- 
proach to exhaustion has already been indicated. 
It will conduce to a wider view to enlarge briefly upon the nature 
and significance of this immediate exhaustion. As pre^^ously discussed, 
it results ultimately from a qualitative deterioration which comes to 
the protoplasm of nucleus and cytoplasm. But absolute dechromatini- 
zation does not stand in the way of complete recuperation. Eecuperation 
Tests upon a deeper foundation than that. Given a young and virile 
animal, recovery after absolute exhaustion may be outwardly at least 
complete. The inherent power to rebuild and to elaborate its energy- 
supplying materials is retained. But from repeated overstrains, even 
among many ceUs from one single exhausting overstrain, something of 
this power is lost. After such overstrains or with natural senescence, 
the distortion of shape, the deficiency in extra-nuclear chromatin, the 
loss of the karyosome, partial and then complete loss of the nucleus and, 
finally in senüity, the disappearance of many ceUs mark the limitations 
of recovery and show the gradual advance of this qualitative deterioration 
and its results (Dolley, 1911a). It is upon the degree of this qualitative 
