The röle of the chondriosomes in the cells of the guinea-pig’s pancreas. 261 
containing spaces of an even diameter, surrounded by, or embedded in 
a denser medium, the protoplasm. The basal and outer zone, in which 
lies the nucleus, exhibits no vacuolation. It is stained by the basic as well 
as the acid dye and therefore appears darker than the inner zone. 
This darker colour is not very marked in material fixed by osmic 
acid fixation. 
After Zenker’s fixation, and Heidenhain’s Iron Alum Haematoxylin 
staining, it is possible to observe a longitudinal striation in this basal 
zone. The striae seem to be continuations of the cytoplasm of the inner 
zone, in which the vacuoles are imbedded, passing into the more compact 
cytoplasm of which the basal zone is composed (Fig. 1). 
Ver Eecke (1895) describes the reticulum as large meshed in the 
inner, and very small meshed in the basal zone, the long threads in the 
latter merely Crossing each other, and not forming a true network as in 
the inner zone. This appears to me to be a correct description only of the 
way in which the threads are arranged in the basal zone, the presence of 
a true network cannot be admitted. 
The striated appearance of the basal zone was first noted by Pflüger 
(1875) and confirmed by Heidenhain. 
A similar structure is also be seen in the cells of the salivary glands. 
The nature of the longitudinal striations has been the subject of 
considerable discussion. Some authors have denied the existence of the 
striae, or have been able to detect in the basal zone only rows of very 
fine granules, or have identified them as the chondriokonts composing the 
chondriosome. 
This latter view is undoubtedly erroneous, for in Zenker’s fixed 
material, stained with Iron Alum Haematoxylin and Orange G. the stria- 
tion can be clearly seen in some cells, where at the same time, lying be- 
tween the striae, certain shadowy masses, very faintly stained by the 
Haematoxylin are also visible. These are easily distinguishable from the 
striae which are stained yellow by the Orange G, and are indeed, the 
imperfectly fixed chondriokonts (Fig. 1). 
The granules of the panereatic eells. 
Three sorts of granules are to be found in the cells of the pancreas, 
all of which are basophile. Tliey are, 
(1) The large granules or mitochondria which occur only in the basal 
zone, mixed up with the chondriokonts. Together these form 
the chondriosome of the cell. 
