IOWA ACADEMY OP SCIENCE 
101 
TABLE I. 
Subject A. 
Date 
Conditions 
Volume, cc. 
Creatinin, 
grm. 
d 
be 
6 
Nitrogen, 
grms. 
Uric acid, 
grm. 
0.388 
24 
0.289 
Average, endogenous 
0.328 
1.7 gruis. nsptriu 
0.328 
26 
3.7 grms. aspirin 
980 
1.04 
2.42 
10.12 
0.601 
27 
2.0 grms. aspirin 
950 
1.07 
2.33 
10.12 
0.481 
28 
2.0 grms. aspirin __ 
980 

2.48 
10.41 
0.446 
29 
2.3 grms. aspirin 
1085 
1.14 
2.50 
12.03 
0.413 
30 
2.6 grms. aspirin 
1580 
1.23 
2.84 
12.92 
0.465 
31 
2.6 grms. aspirin 
780 
1.01 
2.30 
8.62 
0.414 
June 1 
3.3 grms. aspirin 
730' 
1.17 
2.28 
10.89 
0.341 
2 
4.0 grms. aspirin 
1480 
1.09 
2.10 
11.75 
0.411 
3 
1.3 grms. aspirin 
800 
1.09 
2.40 
10.89 
0.360 
4 
2.6 grms. aspirin 
950 
1.07 
2.26 
10.96 
0.366 
5 
3.7 grms. aspirin 
1116 
1.03 
2.55 
11.67 
0.458 
Average, nspirin period 
1.07 
2.41 
10.22 
0.424 
6 
Endogenous 
1025 
1.06 
2.60 
10.57 
0.090 
7 
Endogenous 
1130 
1.13 
2.74 
9.24 
0.278 
8 
Endogenous 
1130 
— 
— 
— 
0.268 
Average, endogenous 
1.10' 
2.67 
9.91 
0.214 
Prom Table I can be seen the response of the organism to the administration 
of salicylic acid. Polin has shown that the creatinin can be taken as a measure 
of the bodily metabolism. If we note the amount of creatinin and total nitrogen 
eliminated we find that the general metabolism was very little affected; whereas 
in general the uric acid increases with the drug. Since there was no increase in 
the phosphorus output the indication is that the increased elimination was 
due to an inhibition of the uricolytic or destructive ferment rather than to an 
increased destruction of the nucleins through a stimulation of the oxidizing fer- 
ment. The great decrease in eliminated uric acid in the after period with no 
corresponding change in the other protein decomposition products has been ob- 
served in other experiments. Possibly the uricolytic ferment becomes under 
these circumstances more than ordinarily active, although some more satisfactory 
explanation may be found. 
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