DE. PAVT ON SUGAE FOEMATION IN THE LIVEE. 
6T)7 
Amount of Amyloid Substance in the Liver of the Log under 
a Liet of Animal Food and Sugar. 
per cent. 
Example No. 17 12‘80 
Example No. 18 17 '55 
Example No. 19 12-33 
Example No. 20 15-37 
Average amount of amyloid substance yielded by the above four analyses 14-5 per cent. 
The relative weight of the liver and the amount of amyloid substance present have 
varied much in the observations that 1 have made on the rabbit. But the better the 
condition of the animal, the larger is the quantity of amyloid substance its liver contains. 
In the two following experiments, the effect produced on the liver by a free administra- 
tion of sugar and starch is strikingly corroborative of the results obtained upon the 
dog. 
In one of the experiments, a couple of full-grown rabbits were taken as near as 
possible resembling each other. One was kept entirely without food; the other was 
fed daily for three days, through a tube passed down the oesophagus into the stomach, 
with one ounce of starch and three-quarters of an ounce of grape-sugar made into a 
semifluid mass with water. On the fourth day both animals were killed. 
Weight of 
Weight of 
Amount of 
animal. 
liver. 
amyloid substance. 
lbs. oz. 
oz. 
per cent. 
Babbit fasting 
. 3 1 
If 
1-3 
Babbit on starch and grape-sugar . 
. 3 4 
2f 
15-4 
The other experiment was [on two half-grown rabbits, likewise as nearly as possible 
resembling each other. One was made to fast, whilst the other was fed on an ounce of 
starch and the same quantity of cane-sugar daily for three days. On the fourth day the 
examination was made. 
Weight of 
Weight of 
Amount of 
animal. 
liver. 
amyloid substance. 
lbs. oz. 
oz. 
per cent. 
Babbit fasting 
1 14 
1 
1-4 
Babbit on starch and cane-sugar 
1 14f 
16-9 
have a record of another experiment, but 
in this the 
amount of 
amyloid substance 
was all that was determined. The rahbit was allowed to take its ordinary food, and in 
addition, three-quarters of an ounce of loaf-sugar and half an ounce of starch were admi- 
nistered daily for three days. The animal was killed on the fourth day. The liver was 
not analysed until the day after death, but it then yielded 22-7 per cent, of amyloid 
substance. 
After the administration of sugar, as in the above experiments, the liver is altered in 
its physical appearance. It becomes of a very pale colour, and so soft that it is readily 
