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XXXIII. Contributions to the Chemistry of the Urine. — Paper III. 
Part IV. On the V iriaiions of the Sulphates and Phosphates in Disease. 
By Henry Bence Jones, M.D.,M.A.Cantah., F.R.S., Physician to St. George's Hospital. 
Received April 19, — Read June 13, 1850. 
IHE object of the following experiments was to determine whether the sulphates in 
the urine were increased or diminished in any class of diseases. The total amount of 
phosphates in the urine in the same diseases was at the same time made the subject 
of experiment, partly to see whether the deductions made in a paper published in the 
Philosophical Transactions for 1846 would be confirmed, and partly to determine 
whether the same disease produced the same or a different effect on the phosphates 
as on the sulphates ; whether, in diseases in which the phosphates were increased the 
sulphates would be also increased in the same proportion ; and whether, in those 
diseases in which the phosphates were diminished, the sulphates also would be found 
to be below the average amount. 
Most of the following experiments were made on the urine first passed in the morn- 
ing before food. When this could not be obtained, the afternoon or night urine was 
taken. Almost all the cases were in St. George’s Hospital, and therefore under nearly 
the same circumstances as regards exercise. The diet usually varied with the state 
of the patient. 
In two papers in the Philosophical Transactions for 1845 and 1849, 1 have shown 
that in the healthy state on full diet the total amount of sulphates and phosphates in 
the urine varies as regards sulphates — 
Spec. grav. 
After food from lT85grs. of sulphate of baryta per lOOOgrs. of urine . 1033'9 
Before food to 7'93grs. of sulphate of baryta per 1000 grs. of urine . . 1026 5 
As regards the total phosphates — 
After food from 7‘22grs. of phosphate of lime per 1000 grs. of urine. . 1030‘0 
Before food to 7*96 grs. of phosphate of lime per 1000 grs. of urine . . 1027’9 
In the following paper I shall give the amount of the sulphates and the total 
amount of the phosphates in the urine : — 
1. In acute and chronic diseases in which the muscular structures are chiefly 
affected. 
2. In some functional diseases of the brain, as delirium tremens and some other 
forms of delirium. 
3. In acute inflammatory disease of the nervous structures. 
4. In chronic diseases of the nervous structures. 
