246 
DR. BENCE JONES ON THE VARIATIONS 
The following course was taken. A healthy man who took food twice daily, and 
moderate exercise for three hours, was the subject of the experiments. A bottle con- 
taining 1000 grains of water was filled with urine, at a temperature of 60°. It was 
weighed, and the fluid was heated to 120°, when a test alkaline solution was dropped 
from a graduated tube, and well-stirred, until the urine became just neutral to very 
delicate test-paper. 
The test solution was prepared by taking dry and pure carbonate of soda, and dis- 
solving it in so much water that every measure of a graduated tube contained ^^th 
of a grain of carbonate of soda in solution. 
To determine the amount of uric acid, upwards of 2000 grains of urine were mixed 
with strong hydrochloric acid, in the proportion of a drachm to the ounce, and left 
to stand for at least twenty-four hours. The fluid was poured off, and the residue 
thrown on a weighed filter, slightly washed, and dried in vacuo over sulphuric acid. 
(1.) Breakfast on bread, coffee, and two eggs, at 9 a.m. Dinner at 7^ p-m. Fish 
meat, and vegetables, with water. 
Acidity per 
Uric acid 
1000 grs. of urine. 
1000 grs. of 
P.M. 
Spec. gr. 
measures. 
grain. 
Water passed at 2 clear. 
1023*1 
9*77 
0*39 
Water passed at 7 clear. 
1026*3 
27-28 
0*048 
Water passed at 1 1 cloudy. 
1030*0 
26*21 
0*584 
(2.) The following day, breakfast as yesterday. Dinner at p.m. 
Water passed at 2 slightest cloud. 
1025*4 
4*88 
0*731 
Water passed at 6^ clear. 
1026*7 
23*37 
0*14 
Water passed at 1 1 clear. 
1025*1 
7 - 8 O 
0*61 
(3.) Following day, breakfast as before. 
Dinner at 6^ 
P.M. 
Water passed at 1 clear. 
1025*5 
9*75 
0*53 
Water passed at 6^ clear. 
1023*1 
22*48 
0*17 
Water passed at 1 1 clear. 
1031*1 
11-64 
0*92 
(4.) As yesterday. Dinner at ^ to 6 p.m. 
Water passed at very thick. 
1027-8 
23*35 
0*53 
Water passed at 5f clear. 
1027-7 
27-24 
0*12 
Water passed at 10| clear. 
1021-0 
13*71 
0*39 
(5.) As yesterday. Dinner at 7 p-m. 
Water passed at clear. 
1023*1 
17-59 
0*44 
Water passed at 7 clear. 
1024*9 
30*24 
0*146 
Water passed at 1 1 clear, 
1026*5 
9*74 
0*634 
Average mean of five days. 
Between 1 and 2 p.m. 
1025*0 
13*07 
0*52 
Between 6 and 7 p-m. 
1025*7 
26*12 
0*12 
Between 10 and 11 p.m. 
1026*7 
13*81 
0*62 
