203 
that the Sakais used a decoction of scrapings of the bark 
and not the sap. The sap, however, is said to contain a small 
amount of Brucine and sap obtained from the stem I have found 
to be intensely bitter). 
At 5-10 p.m. I injected into the abdominal walls, 5 mms. of 
pure :atex of the Antiaris , a very sticky liquid, difficult to inject 
as it clogged the syringe. The breathing of the dog became 
slightly more rapid and it became sleepy, but soon became 
lively again and nothing further happened. At the post mortem 
examination I found no discolouration at the point of injection, 
but the latex had been completely absorbed. 
I cannot account for the failure of the poison to affect the dog, 
unless it was that the part selected was not very vascular and 
the drug was only slowly absorbed. 
I then mixed the two liquids in equal parts, making a much 
more fluid drug easy to inject and injected 10 mm. into the lower 
part of the abdomen, the point of the syringe entering one of the 
mammary glands. Time 5-40. 
5-43. Dog uneasy, yawned much, breathing heavy. 
5-45. Breathing very hard and rapid. 
5-47. Dog vomited, then breathing became easier. 
5-48. Dog retched violently and became very restless. The 
tongue became blue. 
5-50. Slight convulsions. Breathing nearly normal. 
5-52. It lay down and got up again after a minute, and passed 
solid faeces. 
5-54. It stood still with its head hanging down, groaned, and 
frothed at the mouth. 
5-55. It lay half-down, bit at the straw and the cha'n, and 
seemed to be in much pain. The abdomen was 
moving rapidly, apparently convulsed. The dog 
was still sensible, and uttered cries. 
It was then killed wjth a blow on the head, which unfortunate- 
ly broke one of the large vessels in the head or neck, and caused 
a great flow of blood from the mouth. I immediately opened it. 
At the po'nt of injection, one vessel was heavily charged with 
venous blood, and the whole of the gland discoloured. The sto- 
mach was empty and, with the intestines, very pale and blood- 
less. The kidneys pale. The lungs quite ernp.y of blood, as 
were the upper vessels. There wa a lit le in the heart, which 
was not contracted. 
1 could not get any more dogs, so continued the experiments 
on toads ( Bufo melanostictus.). 
I first injected a small toad with the sap of the strychnos and 
poured some dowm its throat, but as this had no effect on it, I 
did not use any more in the rest of the experiments. 
Experiment 2. — At 12-36 p.m. I injected 11 mm. of Antiaris la- 
tex ito the left thigh of a fairly large toad. 
1-5. Great uneasiness. It lay flat on its belly, had slight con- 
vulsions, passed urine. The breathing became very 
hard. The legs very weak. 
