204 
I-15- Pupils of eyes contracted much, but not yet perma- 
nently. It had a spasmodic contraction of 
the fore-legs. When turned on its back it could 
not recover itself. 
It was quite unable to move. The pupils very much 
contracted. Eyes still sensitive to touch. Breath- 
ing very faint. 
I_ 35 * Laid it on its back. Voilent convulsions. Eyes no 
longer sensitive to touch. Spasms of pectoral and 
abdominal vessels. It was practically dead. 
Post-mortem Examination . — Brain normal. Heart still beat- 
ing, momentarily checked by convulsions.- Lungs full of air. 
Vessels of abdomen and chest very full of blood. Stomach and 
intestines; vessels on the outer coat congested, inside not con- 
gested, stomach full of clear shiny liquid, colon full of the remains 
of grasshoppers, &c. Liver congested, gall bladder dark and 
full. (This appears to be always the case after an injection of 
Ipoh .) Kidneys full of blood. 
. P' Another toad was injected with equal parts of Strychnos 
juice and Antiaris milk, at 12-47 P- m - 
12-48. Breathing rapid, sides throb violently. 
1-20. Passed urine and faeces. 
1-25. Commenced to get weak. 
The animal was then pithed and opened. The throat muscles 
were still active. The viscera on the whole were generally less 
congested than in the previous case, except the lungs which con- 
tained more blood. Application of the mixture to the now 
quiescent intestines and stomach produced violent peristaltic 
action (the application of water, and mechanical irritation 
having previously produced no result). Pure Antiaris latex ap- 
plied produced instant and violent contraction of the intestine 
transversely. This contractioi which lasted for some minutes 
was most violent in the colon. 
C.— A similar toad injected at 1 p.m. with 5 mms. of the mix- 
ture. 
1-2. Abdomen commenced to twitch. Beat of the heart be- 
came more violent. 
1-5. Twitching of the abdomen increased in violence. Toad 
attempted to vomit once. 
1-20. It commenced to lose the powder of its limbs. Passed 
excreta. 
1-25. Pupils contract. Breathing very faint. 
1-55. Nearly dead. Eyes but little sensitive to touch. 
2 p. m. Quite dead. 
Post mortem examination. — Brain normal but with more liquid 
above it than usual. Lungs full of air. Heart black at the 
apex, outer wall congested, auricles full. Liver and spleen con- 
gested, as were the mesenteric and other abdominal vessels. 
Gall bladder full and black, much perivisceral fluid. 
