205 
D. — Administered 5 mm. of the mixture by the mouth, to a 
toad. No effect. 
E. — At 3-30 p.m. injected into a toad 5 mms. pure Antiaris 
latex, at 3-40 it was very weak, at 3-50 it had slight convulsions, 
at 4-0 it died. The action of unmixed Antiaris is much more 
rapid than the mixture. 
F. — A toad was pithed and opened. Antiaris latex applied 
to the heart produced irregularity of beat, viz : — 
32 beats in 25 seconds. 
19 ,, in 14 ,, 
20 ,, in 17 ,, 
27 ,, in 25 
The intestines, specially the colon, contract violently when the 
Antiaris latex is applied to it at the point of application. 
G. — A toad was pithed and the thorax opened, and the heart 
beats recorded at 4 p.m. 
At first there were ... • • • 25 beats in 15 seconds. 
Antiaris latex applied to heart... 20 ,, ,, ,, 
A second application ... ... 21 ,, _ ,, 
3mms. injected under skin of thigh 24 increasing to 27 ,, 
The sides began to twitch, and a second 
injection as before was given 26 beats in 15 seconds. 
Convulsions set in. More Antiaris milk was applied to the 
heart, and the action became irregularf 23 beats). . 
Irregularity of heart action increases, and the action is weaker 
(21 beats). Convulsions every two or three minutes. 
Heart very irregular and feeble 20 beats. 
At 4*20. The beats had fallen to 13I in 15 seconds. 
fi-Two toads were pithed and an opening made over the 
heart. In No. 1 the upper part of the heart was slightly cut by 
accident but not so as to inflict any real injury. 
No. 1. Heart beats in 15 seconds ... ... ... i6£ 
Antiaris applied to base of heart ... ... 20 
After a few minutes fell to ... ... 18 
Pupils much contracted and nearly closed. 
Injected 2 mm. into thigh ... ... 22 
Violent spasms ... ... • • • • ■ * 23 
The heart beats now became more pronounced, and the animal 
became weaker and weaker till life was almost extinct. Electric 
shocks were adminstered which, did not affect the heart, but 
only the motor muscles. 
No. 2. Normal heart beats ... ... 18^ in 15 seconds 
At 8.54 p.m. injected 2 mm. 
Antiaris milk — ■ * * • 19 f° 20 
At 9 p.m. a very slight contraction of the pupil. The heart 
beats still normal. 
9-3. Slight spasms of the abdomen. Beats ... 17 
9-10. ,, „ „ >> 9 
9-25. „ „ » » b 
