the use of the Colchicum autumnale in gout. 265 
the mouth to the same dog: the effect was less, than in my 
experiment with the vinous infusion of Colchicum exhibited 
in the same quantity : this arose from a yery copious evacua- 
tion of urine having been produced. 
Exp. 3. One hundred and sixty drops of the Eau Medi- 
cinale, injected into the jugular vein of a dog, produced rather 
more violent effects, than in my experiment with the same 
quantity of vinous infusion of Colchicum ; the animal died in 
6 hours, and after death the appearances of inflammation in 
the bowels, were more violent, approaching to mortification. 
Mr. Gatcombe having found so exact a similarity in the 
effects of the two medicines, in these trials, I requested him 
to make the following comparative experiment on the effects 
produced upon the stomach and bowels by the Eau Medici- 
nale, in which there is a deposit, and the vinous infusion of 
Colchicum, in which there is none. 
Exp. 4. One hundred and sixty drops of the Eau Medici- 
nale, taken by the mouth, produced the same effects, and left 
the same appearances after death, as when that quantity was 
injected into the vein, only the animal lived 9 instead of 
6 hours. 
One hundred and sixty drops of the vinous infusion of 
Colchicum, were given to a puppy of the same litter; they 
produced vomiting, purging, and a great flow of urine ; but 
the animal very soon recovered. 
Two hundred drops of the same infusion, after an interval 
of several days, were given to the same dog, and the effects 
were the same ; the dog had become much improved in his 
looks and condition. 
Three hundred drops, after an interval of several days, 
were given to the same dog: effects, corresponding with 
