266 Sir Everard Home’s farther observations on 
those of 160 drops of the Eau Medicinale, were produced. 
The dog died in 9 hours, and the appearances of inflamma- 
tion after death were of the same kind, but not nearly so 
extensive. 
From these experiments the Eau Medicinale with the 
deposit, produces double the irritation on the coats of the 
stomach and intestines, that is brought on by the vinous 
infusion of Colchicum : this probably arises from the local 
inflammation brought on by the deposit, upon the internal 
membrane of these viscera. 
To determine as nearly as possible the effects of the depo- 
sit, when applied in a solid form, to the coats of the stomach 
and intestines, the following experiment was made. 
Exp. 5. Six grains of the deposit of the vinous infusion of 
Colchicum, were given to a dog in bread and milk; in 3 
hours it produced vomiting and purging, which lasted 24 
hours ; during the latter part of that time, there was blood in 
the stools, as well as in what was brought up from the 
stomach. 
I wished to repeat this experiment with the deposit from 
the Eau Medicinale, but found in bottles that had been kept 
7 years, the wine had become vapid, and, in this decomposed 
state, the acrid part of the deposit had been taken up again ; 
so that in 12 bottles, containing different quantities, only 5 
grains could be procured, which was quite inert. 
Being at a loss to know whether the extractive matter 
deposited from the infusion, is in reality more acrid to the 
stomach than that suspended in it, or the circumstance of its 
being applied in a solid form renders it so, I requested 
Professor Brande to acquaint me, if it could be the effect of 
any chemical decomposition having taken place. 
