OF THE BARK OF ERYTHROPHLEUM GUINENSE. 
629 
seemed giddy, and rolled over on trying to walk. Faeces were passed. Respirations 
80, gasping. At 10' it was lying on its side with its mouth wide open ; respirations 
120. At 10' 30" the respirations were 160, gasping. At 11' it made feeble and unsuc- 
cessful attempts to vomit ; the respiration became intermittent ; there was an oscillating 
movement of the eyeballs, and the pupils were widely dilated. At 12' the respiration 
became slower, as well as irregular. At 16' it was 60, irregular and laboured. At 
21' the respiration appeared to be entirely diaphragmatic. At 24' there were strong, 
ineffectual attempts at vomiting, followed by sudden stoppage of respiration, and death 
in a condition of emprosthotonos. The pupils at that time w 7 ere widely dilated. 
On opening the thorax immediately after death, the ventricles were found firmly con- 
tracted ; but they recommenced to pulsate, and continued to do so for a few minutes 
spontaneously. They responded by a single contraction to irritation for 3^ hours after 
death. By this time the heart looked quite dry and glazed, and rigor mortis was well 
marked in the muscles. The lungs were pale. 
Experiment II. — February 22. 
Effects of a Moderate Dose. 
Three cub. centims. of the same alcoholic solution were injected into the abdominal 
cavity of a cat weighing 2238 grammes. At 25 minutes afterwards the animal vomited ; 
and this was repeated at 35' and 41'. At 41' the cat seemed weak ; respirations laboured, 
60 per minute; pulse 100, regular. At 55' respirations 80, shallow, irregular. At 75' 
respiration deeper and more laboured. At 85' the gait was staggering, and the limbs 
were moved with a jerk at the end of each step; respirations 40, more regular; pulse 
100, regular. Four hours after injection the animal was sleepy ; when roused it walked 
feebly ; there was no further vomiting. Its condition remained unaltered as long as it 
was observed; and it died between eight and twenty hours after the injection. 
On post mortem examination rigor mortis was well marked. The abdomen contained 
some yellow serum. The stomach contained no solid food, but about two ounces of a 
greyish turbid alkaline fluid. 
Experiment III. — April 28. 
Seven cub. centims. of a similar solution to that used in Experiments I. and II. were 
injected beneath the skin of a moderate-sized, well-nourished cat; In fifteen minutes 
the animal vomited for the first time, and this vomiting was repeated four times within 
the next hour and twenty minutes. During the rest of the day it remained quiet, with- 
out further vomiting, and with no paralysis or disturbance of muscular movements. It 
appeared to be quite comfortable. 
On the following day it remained sitting in one position, and refused its food and 
milk. There was no vomiting, and no urination or defsecation. When disturbed, it 
would immediately return to its former position in a mechanical manner. 
On the following day it passed a very small quantity of ffeces ; it was not observed to 
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