OF THE BARK OF ERYTHROPHLEUM GUINENSE. 
639 
Experiment XXV. — May 17. 
This experiment was similar to Nos. XXIII. and XXIV. As before, no vomiting was 
produced by injection of the drug after section of the vagi, but death occurred one hour 
and ten minutes after the injection, in consequence of dyspnoea occasioned by the 
section of these nerves. 
Action of Casca on Respiration. 
Powdered casca, when inhaled, acts as a violent sternutatory. All the men employed 
by us in grinding or pounding the bark suffered severely from the violent and irresistible 
fits of sneezing which attacked them ; and in one instance these were accompanied by 
great faintness and tendency to syncope. 
When injected into the circulation casca greatly accelerates the respirations (Experi- 
ments I., II., XXXIV.). 
This acceleration appears to be due to stimulation of the pulmonary branches of the 
vagus, and not to any action of the drug upon the respiratory centre, as no acceleration 
is noticed when the vagi are divided before the injection of the casca (Experiments 
XXIII. and XXIV.). 
Action on the Intestines. 
Experiment XXVI. 
In order to ascertain whether the intestinal secretion was increased by casca, a cat 
was chloroformed, the abdomen opened, and three loops of small intestine ligatured. 
Into the middle loop 2 cub. centims. of a concentrated solution of the watery extract 
of casca were injected, and 2 cub. centims. of water into the other two. The cat vomited 
about an hour afterwards. At the end of about 5 hours, the animal was killed and the 
body examined. The upper and middle loops were both dry, and the mucous mem- 
brane was normal in appearance, except slight congestion at the place of ligature 
between the upper and middle loop. The lower loop contained several cubic centims. 
of turbid greyish fluid. 
The intestinal secretion is thus seen not to be increased by the drug. 
Action of Casca on Circulation. 
Experiment XXVII. 
Preliminary Experiments on Frog's Heart. 
A watery solution of the alcoholic extract and a standard salt solution were prepared ; 
the hearts of two frogs of about the same size were then removed, and placed for a 
minute or two in ‘75 percent, salt solution. When they had recovered from the shock 
of removal, and were beating regularly, one was placed in the casca solution, the other 
in the salt one. At the commencement of the experiment the heart, A, placed in salt 
solution was beating at the rate of 6 per 10 seconds; the heart, B, in casca at the rate 
of 75. Both hearts became weaker and their pulsations slower; at the end of 50 
