642 
DR. T. L. BRUNTON AND MR. W. PYE ON THE ACTION 
Experiment XXXIII. — March 31. 
Action on the heart and blood-pressure of a large dose of casca. (For action on 
secretion of urine also, vide infra.) 
A bitch, weight 26^ lb., was chloroformed. 
A cannula was placed in the trachea. 
,, „ left femoral vein. 
„ „ right ureter. 
„ „ left carotid artery. 
The operation was very long, and during it the intestines became much congested. 
Amount 
1 
of Urine 
secreted 
Blood- 
Oscilla- 
Pulse. 
per 10 
pressure. 
tions. 
minutes. 
minims. 
5 
120 
10 
20 
■ 
140 
10 
20 
7 
140 
10 
20 
24 
145 
10 
20 
160 
15 
20 
i.7 
160 
15 
20 
17 
140 
25 
20 
165 
CD 
o o 
10 
3 
200 
r is 
1 20 
20 
180 
r 10 
\ 20 
16 
5 
150 
30 
15 
13 
110 
50 
121 
9 
115 
30 
16 
150 j 
r i6o 
[140 
4 
30 
1 
170 j 
[ 190 
150 
2 
40 
Respi- 
ration. 
h. m. s. 
1 54 57 
2 7 40 
0 8 10 ' 
0 10 30 
0 17 40' 
I 2 27 40 
j 2 34 30 ' 
2 34 40 
2 35 40' 
2 47 40 
2 57 40 
3 0 10 
3 0 30 
3 2 40 
7 40 
17 40 
27 40 
37 40 
37 50 
38 10 
3 40 0 
3 42 0 
Normal condition before experiments 
The rate of secretion of urine was estimated at two 
successive periods of 10 minutes each. 
4 cub. eentims. casca solution injected into femoral 
vein. 
Showing the ordinary effect of the injection of a small 
quantity 
Urine increased in quantity, alkaline, turbid, not albu 
minous 
Urine still further increased 
Is clear ; not albuminous. 
5 cub. eentims. more injected. 
Showing effect of further injection 
Urine secreted, clear as before 
Clot formed. Lost about 15 cub. eentims. of blood. 
Urine as above 
With the increased dose the pulse-oscillations have 
begun to be affected as well as the blood-pressure 
10 cub. eentims. more injected. 
Showing the immediate effect of a large dose. The 
systole and diastole are nearly equal; there is a 
very powerful action of the heart and increased 
blood-pressure 
Showing the later effects of a large dose. The oscil- 
lations of the pulse are less, while the blood-pres- 
sure is greatly increased. The secretion of urine 
is much diminished 
Secretion of urine stopped 
Urine has again commenced to be secreted, the blood- 
pressure having fallen somewhat 
Urine secretion again increased 
Further injection of 15 cub. eentims. 
The blood-pressure is now much affected by the re- 
spiration after the injection of a large dose 
This is still more marked 
The blood-pressure gradually fell, and the pulse was 
too feeble to write on the kymograph, while there 
was still a rise of blood-pressure synchronously 
with the respirations, which stopped at 3 h. 43 min. 
