OF THE BARK OF ERYTHROPHLEUM GUINENSE. 
657 
less sensitive to pinching, and insensibility and loss of motor power occurred simulta- 
neously in both. 
The diminished power of movement and diminished reflex action observed in the frog 
after the administration of casca is therefore due to the arrest of the circulation caused 
by it, not to any action of the drug upon the nervous system. 
Antagonism between Casca and Atropia and Chloral Hydrate. 
The remarkable result of Experiment XXIV., in which a dose of casca, usually fatal, 
produced no effect in an animal with divided vagi, seemed to render it probable that 
such a drug as atropia, which paralyzes the ends of the vagus in the heart, might have 
an antagonistic action. On trying it, however, it was found that the vomiting caused 
by the casca was even more violent than usual ; and therefore a combination of atropia 
with chloral hydrate was employed, the chloral being given to lessen the irritability of 
the vomiting centre in the medulla. 
The results were not satisfactory, as will be seen from the two following experiments. 
Experiment LV. — May 1, 1876. 
About 11.40. Injected 4 cub. centims. of liquor atropise under skin of flank of cat A. 
12 h . Injected 4 cub. centims. of a saturated alcoholic solution of alcoholic extract of 
casca under skin of flank of cats A and B. 
A. 
B. 
h. m. 
12 30 
Sick and vomits. During the intervals between 
12 40 
Crouching, trembling, and seems about to be sick. 
the fits of vomiting seems well. 
12 52 
Licks its lips. Hind eyelid much drawn up. 
Very sick ; vomiting. Seems more uneasy than 
Vomiting. Disinclined to move. When dis- 
B. 
turbed and made to walk its hind legs give a 
1 0 
Very sick. 
shake as if to shake off something sticking to 1 
the feet every time they are drawn up. 
Very sick. Brings up fluid, which appears to be 
1 15 
Gives loud squalling cries when retching. 
digested meat. Respirations 18 per minute. 
Seems weaker. 
1 30 
Seems easier ; not retching. 
Twitch or rather shake of hindlegs isvery marked. 
2 35 
Walking about. 
Seems unable to move. 
2 40 
Violent retching ; crying. Convulsive extension 
4 0 
Has been vomiting at intervals. Has a violent 
of legs and emprosthotonos. Then two or 
three sighing respirations ; a pause ; one or 
two respirations at intervals ; then death. 
fit of sickness and dies in the same way as B. 
Post me 
i rtem. 
Stomach contains a quantity of food. Heart 
Stomach empty, not congested. Heart mode- 
moderately contracted. Ventricles continue 
rately contracted. Lungs normal. 
to make slight pulsations, auricles not. Lungs 
somewhat congested. No congestion of inte- 
rior of stomach. 
