500 ME. J. PEIESTLEY ON THE PHYSIOLOGICAL ACTION OE VANADIUM. 
In this experiment 5 milligrammes of V 2 0 5 caused death in a frog within 36 hours. 
The noteworthy points are that a gradual and general paralysis occurred, that the 
intestinal tract was congested, and that it contained a greenish mucus. 
Exp. IX. — February 20, 1874. 
Weight 24 - 5 grms. (English frog). 
Dose 1 cub. centim. of the 5 per cent, solution (50 milligrammes V 2 0 5 ), injected 
under the skin of the back. 
From this experiment we learn that paralysis appeared within 40 minutes of the time 
of injection, that the heart was so affected as to die on exposure sooner than an 
unpoisoned heart would probably have done, that the irritability of voluntary muscles 
and of motor nerves was unimpaired. 
Exp. X.— February 20, 1874. 
Weight 29 grms. 
Dose 1 cub. centim. of the 5 per cent, solution (50 milligrammes V 2 0 5 ), injected 
under the skin of the back. 
Note . — A certain amount of the solution escaped during injection. 
This experiment serves to corroborate the preceding. 
Exp. XI.— May 27, 1874. 
Weight 29 grms. 
Dose 1 cub. centim. of the 5 per cent, solution (50 milligrammes V 2 0 5 ), injected 
under the skin of the back. 
This experiment shows that vanadium-poisoning causes paralysis of respiration, 
general paralysis of voluntary muscles, injury to the power of reflex activity, without 
affecting muscle, nerve, or conducting-power of cord directly. 
On a Pigeon. 
Exp. XII. — February 25, 1874. 
The pigeon was healthy and rather young. 
Dose - 5 cub. centim. of the 5 per cent, solution (25 milligrammes V 2 0 5 ), in- 
h. m. jected under the skin of the breast. 
3 47. Injection complete. 
4 30. Quiet, but otherwise normal. 
5 15. Discharge of faeces, green in colour. 
6 10. Further discharge of faecal matter, which is now of a red colour and very watery, 
containing blood-corpuscles and epithelial cells. 
6 30. Further discharge of sanguineous fluid faeces. 
9 48. Sanguineous faecal discharges have continued in the meantime. 
