MR. J. PEIESTLEY ON THE PHYSIOLOGICAL ACTION OF VANADIUM. 503 
(as in peritonitis) ; possibly an impairment of sensibility ; post mortem appearances of 
congestion of the alimentary mucous membrane, with blood-extravasations. The blood 
was uninjured by the poison as far as its optical properties indicated. 
Exp. XIV.— January 14, 1874. 
Weight 595 grins. 
Dose 2 cub. centims. of the 5 per cent, solution (100 milligrammes V 2 0 5 ), 
injected under the skin. 
This experiment shows that 100 milligrammes of V 2 0 5 produced death in 3 hours 
25 minutes ; that symptoms of poisoning appeared within eight minutes of the time of 
injection; that the chief symptoms were drowsiness, a convulsive movement of the 
limbs, head, and body, with general weakness or inability to move easily ; that sensation 
appeared unimpaired ; and that respiration became difficult towards the close of the ex- 
periment. After death the alimentary canal appeared to have suffered slight but distinct 
congestion in portions, and the lungs were also congested. 
Exp. XY. — January 21, 1874. 
Weight 755 grms. 
Dose ’5 cub. centim. of the 5 per cent, solution (25 milligrammes V 2 0 5 ), 
injected under the skin of the right shoulder. 
h. m. 
8 51. Injection complete. 
9 10. Very uneasy; runs round box uttering slight cries. Twitches of head. Dis- 
charge of watery faeces. 
10 0. Belly very unduly swollen on the side on which the injection was made, due 
probably to tympanitis. 
10 10. Contrives to get into a corner and moans, twitching its head convulsively. 
Discharge of urine. No observation was made prior to injection as to the 
state of the pupils ; but from a comparison with other animals they would 
seem to be dilated : they are quite sensitive to light. 
10 25. Hemiplegia of right side very marked. 
10 30. Respirations 132 per minute (22 in 10 seconds). (The heart-beats were so 
feeble that they could not easily be counted.) 
10 45. Cries when the abdomen is touched. 
11 0. Urine and faeces discharged ; utters low cries. Can move quite well and 
normally. 
11 25. Evidently very uneasy ; cries continually. Respirations 140 per minute (23'3 
in 10 seconds). 
12 0. Still sensitive. 
12 15. Walks about normally. 
12 35. Respirations 132 per minute (22 in 10 seconds). 
