ME. J. PEIESTLET ON THE PHYSIOLOGICAL ACTION OF VANADIUM. 505 
evident traces of great congestion of alimentary mncons membranes (especially at the 
free border of the small intestines) and of the lungs. 
Exp. XVI.— February 18, 1874. 
Weight 667 grms. 
Dose 1 cub. centim. of the 5 per cent, solution (50 milligrammes of V 2 0 5 ), 
injected under the skin. 
In this experiment 50 milligrammes of V 2 0 5 produced death in 23 minutes from 
the time of injection. Symptoms began to appear within 10 minutes of injection. The 
symptoms were such as we have seen in preceding experiments, viz. indifference to sur- 
rounding circumstances, paralysis, especially of the hind limbs. The heart’s vitality was 
not affected. 
On Babbits. 
Exp. XVII.— January 23, 1874. 
Weight 1373 grms. 
Dose 4 cub. centims. of the 5 per cent, solution (200 milligrammes V 2 0 5 ), 
injected under the skin of the right shoulder. 
In this experiment 200 milligrammes of V 2 0 5 produced death in a rabbit of 1373 
grms. in 12 minutes. The poison produced death clearly by acting at once upon the 
nervous system, causing severe convulsions, and without inducing decided inflammation 
of the alimentary mucous membranes. 
Exp. XVIIT. — February 6, 1874. 
Weight 1705 grms. 
Dose *5 cub. centim. of a 5 per cent, solution (25 milligrammes V 2 0 5 ), 
injected under the skin. 
From this experiment we learn that 25 milligrammes of V 2 0 5 produced death in a 
rabbit of 1705 grms. in 49 minutes ; that symptoms of poisoning set in within 30 minutes 
of injection. The symptoms agree with those of the previous experiment ; and, coin- 
cident with the shallow and rapid respiration, there was a fall of 1°'5 C. in temperature. 
The temperature in the rectum remained constant for some time after death. 
Exp. XIX. — February 11, 1874. 
Weight 1449 grms. 
Dose 1 cub. centim. of a '25 per cent, solution prepared from the standard 
5 per cent, solution (2*5 milligrammes V 2 0 5 ), injected under the skin. 
In this case a very small dose was injected; and no symptoms, distinctly attributable 
to poison, followed, except a slight indifference to external objects. 
4 A 
MDCCCLXXVI. 
