506 ME. J. PEIESTLET ON THE PHYSIOLOGICAL ACTION OF VANADIUM. 
Exp. XX. — February 13, 1874. 
Weight 1449 grms. 
Dose 1 cub. centim. of a ’5 per cent, solution prepared as above (5 milli- 
grammes V 2 0 5 ), injected under the skin. 
(This was the same rabbit as was used in the preceding experiment.) 
In this experiment 5 milligrammes of V 2 0 5 produced in a rabbit of 1449 grms. 
distinct symptoms of poisoning, but no fatal result. The symptoms were, as before, 
partial paralysis, paraplegia of the lower extremities, slight convulsions, excited respi- 
rations, drowsiness, and they appeared within 25 minutes of injection. 
Exp. XXI.— February 18, 1874. 
Weight 1392 grms. 
Dose 5 cub. centims. of the 5 per cent, solution (250 milligrammes V 2 0 5 ), 
injected under the skin of the belly. 
Heart-beats in 10 seconds . 52 1 
,, ,, . 53 I 
t, . , • • in j no determined prior to injection. 
Inspirations m 10 seconds . 22 [ 1 J 
12 37 0. 
12 39 30. 
12 40 0. 
12 42 0. 
12 44 0. 
12 46 30. 
12 47 0. 
„ „ • 24 J 
Injection complete. 
Weakness of posterior extremities. 
Almost complete paralysis of posterior extremity of body. 
General agitation, alternating with an appearance of somnolence. 
Breathing has almost ceased. Quivering over hind quarters. Heart 
exceedingly weak and slow. 
Twitching of head to one side. General convulsive [movements of an 
opisthotonic character. Quivering, and dilatation of pupil. 
Cornea insensitive ; pupil dilated. Jaws open once or twice in a gasping 
manner. Death. 
Post mortem Examination. 
Heart feebly pulsating ; both ventricles moderately distended. Vena cava 
not much distended. Lungs somewhat pale. Lower part of small intestine 
normal. Duodenum and upper part of jejunum contained much glairy 
mucus, which in some places was frothing. Mucous membrane seems to be 
slightly swollen and congested. 
In this experiment 250 milligrammes of V 2 0 5 produced death in a rabbit of 1392 
grms. in 10 minutes, the poison commencing to operate within 2| minutes of injection. 
The symptoms, as before, were paralysis of hinder extremities, convulsions, drowsiness, 
an affection of respiration and of the cardiac movements, and congestion of alimentary 
mucous membrane. 
