ME. J. PEIESTLET ON THE PHYSIOLOGICAL ACTION OP VANADIUM. 511 
“ The liver was examined in the same way, and the blue colour due to 
vanadium was obtained on adding oxalic acid ; but the coloration was not so 
dark as in the case of the intestines.” 
In this experiment 500 milligrammes of V 2 0 5 caused death in a young and small 
dog in 11 hours 5 minutes, poisonous symptoms developing about 15 minutes after in- 
jection. The prominent symptoms were the vomiting of a thick, ropy mucus, salivation, 
and the almost continual discharge of at first a watery and afterwards a sanguinolent 
fluid ger rectum. Respiration was irregular, and afterwards laboured and heavy. No 
nervous symptoms, such as were so characteristic in the case of rabbits, guineapigs, and 
frogs, were observed ; and the animal was evidently conscious to the last. A 'post mortem 
examination disclosed evidences of an intense congestion of alimentary mucous mem- 
branes accompanied by distinct extravasations of blood. The blood coagulated normally, 
but yielded very little serum. Muscles retained their irritability to mechanical stimuli. 
Vanadium was discovered to be present in the tissues (not free from blood) of the liver 
and intestines. 
Exp. XXVII.— February 20, 1874. 
The dog used was a young English (black and tanned) terrier. 
Dose 20 cub. centims. of the 5 per cent, solution was evaporated down care- 
fully to a bulk convenient for subcutaneous injection. The dose equalled 
1 grm. V 2 0 5 . 
In this experiment 1 grm. of V 2 0 5 caused death in a young and small dog in 7 hours 
55 minutes, symptoms developing within 20 minutes of injection. The symptoms in the 
main confirm those of the preceding experiment, except that salivation did not occur here. 
On Cats. 
Exp. XXVIII. — December 12, 1873. 
The cat was small and adult. 
Dose 5 cub. centims. of the 5 per cent, solution (250 milligrammes V 2 0 5 ), 
injected under the skin of the back. 
h. m. 
2 20. Injection complete. 
2 22. Vomits. 
2 23. Discharge of faeces. 
2 28. Again sick. 
2 30. Great contractions of abdominal muscles and diarrhoea. Again sick. 
2 35. Vomits a watery fluid. 
2 37. Respirations about 15 in 10 seconds. Very much depressed; attempts to dis- 
charge faeces. 
2 45. Respirations 16 in 10 seconds. 
2 50. Salivation, the saliva being viscid. Respiration irregular, heavy, and chiefly 
abdominal. 
