ME. J. PEIESTLET ON THE PHYSIOLOGICAL ACTION OE VANADIUM. 513 
of rabbits, &c. The post mortem appearances resembled exactly those in the cases of the 
dogs, but, owing to the rapidity of death, they were not so extensive or marked. 
Chemical examination of the intestines failed to show the presence of vanadium. 
Exp. XXIX. — February 18, 1874. 
Weight 1310 grms. A small cat. 
Dose 1 cub. centim. of the 5 per cent, solution (50 milligrammes V 2 0 5 ), 
injected under the skin. 
In this experiment 50 milligrammes of V 2 0 5 caused the death of a small cat. As far 
as was observed, the symptoms were those of irritation of the alimentary mucous mem- 
branes, viz. vomiting, retching, and congestion of the interior of the stomach and intes- 
tines. The intestines, in their lower portion, contained much brown mucous fluid ; and 
epithelium-cells, hlood-, and mucus-corpuscles were found free in the stomach. The 
lungs were much congested and frothy. 
ii. Action of the Drug when introduced into the System by direct Injection into 
Blood-vessels. 
Only one experiment was performed with the express object of determining the effect 
of direct injection into the vascular system. In investigating the special action of vana- 
dium upon circulation and respiration, however, frequent use was made off this mode of 
injection; and reference will be made, in the Resume of the General Action of Vana- 
dium (p. 518), to the experiments then performed. 
Exp. XXX.— December 5, 1873. 
The dog was a small rough terrier, rather young. 
Dose 2 cub. centims. of a 5 per cent, solution (100 milligrammes V 2 O s ), 
injected into the right external jugular vein. 
Note. — Some of the solution was lost during injection. 
In this experiment (less than) 100 milligrammes of V 2 0 5 were insufficient to cause 
death in a small young dog when directly injected into a vein. The only symptom 
attributable to vanadium-poisoning was the drowsiness which followed on injection. On 
comparing this experiment with Experiment XXVI., in which 500 milligrammes of 
V 2 0 5 injected subcutaneously produced death in about 11 hours, it seems probable that 
a considerable quantity of the solution was lost in this experiment during injection. 
For further observations of the action of vanadium on the system, when injected 
directly into blood-vessels, see Experiments XLII. to LX. (on Circulation and on 
Respiration). 
4 B 
MDCCCLXXVI. 
