ME. J. PEIESTLEY ON THE PHYSIOLOGICAL ACTION OF VANADIUM. 
517 
Liver appears normal. 
Congestion of abdominal viscera. 
Normal peristaltic action of the intestines. 
Stomach filled with bright green contents. Walls much congested, espe- 
cially near the cardiac end and lesser curvature. 
Duodenum filled with bright green contents. The mucous membrane is 
covered with a thick yellowish tenacious matter, which hides a deep con- 
gestion beneath. 
Jejunum contains a darker green substance, and is also much congested in 
its mucous membrane. 
Ileum presents the same appearance as the jejunum. 
Rectum not congested. 
Kidney not congested. 
GEsophagus not congested. 
In this experiment 250 milligrammes of V 2 0 5 caused death in a guineapig within 
27 minutes. Death was preceded by the vomiting of a greenish fluid, an unsteadiness 
of gait and great apparent weakness, a gasping respiration, and convulsive twitches of 
head and hind limbs. A. post mortem examination disclosed a congestion of the lungs 
{Is this due to the action of vanadate of sodium V) and intestinal mucous membranes, as 
well as the presence in the alimentary canal of green contents. 
Exp. XXXV.— September 17, 1874. 
Guineapig. — Weight 505 grms. 
Dose 1 cub. centim. of the 5 per cent, solution (50 milligrammes 
V 2 0 5 ), injected into the stomach. 
In this experiment the animal died in less than a day after injection. The symptoms 
were trembling and an excessive discharge of urine. The urine was tested by shaking 
it up with ether containing hydrogen peroxide, which causes with vanadic acid a red 
coloration ; it contained no vanadic acid in such amount as to be capable of detection. 
Th e post mortem appearances indicated gastric congestion. 
Exp. XXXVI.— September 18, 1874. 
Guineapig. — Weight 463 grms. 
Dose 2 cub. centims. of the 5 per cent, solution (100 milli- 
grammes V 2 0 5 ), injected into the stomach. 
Sept. 19. — The guineapig had died in the night. 
In this experiment the guineapig died in less than a day after injection. The only 
symptom noticed during the five hours of observation immediately after injection was 
an excessive secretion of urine. 
