522 ME. J. PEIESTLET ON THE PHYSIOLOGICAL ACTION OF VANADIUM:. 
As before, the numbers represent the distance in centimetres between the two coils. 
Time. 
Leg whose nerve was immersed in Ha Cl solution. 
Leg whose nerve was immersed in V 2 0 5 solution. 1 
h. m. 
4 30 
Nerve immersed. 
Nerve immersed. 
4 50 
Moves when the distance is 28-30. 
Moves when the distance is 27. 
5 0 
„ „ 27. 
„ „ 27. 
5 15 
„ „ 25. 
„ ,, 25. 
5 30 
„ „ 24. 
„ „ 17. 
5 45 
„ „ 23. 
Twitches with distance 16. 
6 7 
„ „ 21. 
„ „ 11. 
6 40 
„ „ 21-22. 
„ „ _ 6. 
8 0 
„ „ 19-20. 
No movement at all with the secondary coil 
at 0. 
Exp. XLI. — June 1875. 
The above experiment was repeated exactly, except that the strength of the vana- 
dium solution was equal to '05 per cent. V 2 0 5 . At intervals during the experiment 
the muscles of both legs were tested by direct stimulation, and found to be normal as 
to their irritability throughout. 
Helmholtz’s arrangement was not used. With the preliminary stimulation, while 
still in the body, both legs moved when stimulated with the secondary coil at 31-32 
centims. Within 2 hours 40 minutes the nerve immersed in the '05 per cent, solution 
of vanadium salt ceased to induce contraction in the attached muscles on application of 
electrical stimuli ; while, on the other hand, the nerve immersed in the salt solution 
remained sensibly normal for more than 10 hours 45 minutes, when observations 
were discontinued. 
The direct application of very dilute solutions of sodium vanadate rapidly causes 
death in nervous tissue. 
Resume of the action of Vanadium upon Muscle and Nerve on direct application. 
Direct application of vanadium solutions to muscular and nervous tissues is rapidly 
fatal to them. 
iii. Special Action of the Poison on the Function of Circulation. 
The following experiments were undertaken with a view to detect the causes of the 
disturbance of circulation, by determining the special parts of the circulatory system 
affected by vanadium. In the experiments the blood-pressure was recorded by means 
of a mercurial kymographion, continuous tracings being often taken during the whole 
time occupied by the experiment. The rate of rotation of the cylinder was checked by 
means of an electro-magnetic marker, the circuit being made and broken by Ludwig’s 
Stromunterbrecher. 
Both injection under the skin and injection into veins were made use of. 
