ME. J. PRIESTLEY ON THE PHYSIOLOGICAL ACTION OP VANADIUM. 528 
Exp. XLII.— March 4, 1874. 
Eabbit. — Weight 1343 grins. 
Dose 5 cub. centims. of the 5 per cent, solution (250 milligrammes 
V 2 0 5 ), injected under the skin. The kymographic cannula was 
inserted into a carotid artery. 
The rabbit died in 19 minutes 35 seconds after injection, and exhibited the usual 
general symptoms (see Experiments on pp. 505-508). 
Note . — The solution was afterwards discovered to be under strength ; hence the rela- 
tively long time the rabbit took to die. 
Owing to the slight excursions of the pen at each heart-beat, it was impossible to 
obtain from the tracing of the experiment a series of numbers indicating rapidity of 
pulse. 
From the record of the experiment we learn that, after the momentary rise due to the 
insertion of the injecting-syringe and the commencement of injection, the blood-pressure 
exhibited a succession of alternate rises and falls, gradually, however, attaining a lower 
and lower level until the death of the rabbit 19 minutes 35 seconds after injection. 
This alteration in the blood-pressure, as is shown by the tracing taken at the time, took 
place very regularly, and was only occasionally accompanied by struggles. 
Exp. XLIII.— March 30, 1874. 
Eabbit. — Weight 1834 grms. 
Dose 5 cub. centims. of the 5 per cent, solution (250 milligrammes 
V 2 0 5 ), injected under the skin. 
The method of experiment resembled that of the foregoing. The rabbit died 
10 minutes 30 seconds after injection. In this experiment, also, it was impossible to 
count the pulse from the kymographic tracing. 
We learn that vanadium-poisoning causes the blood-pressure to fall from the moment 
of injection until death, that there are occasions on which the blood-pressure reasserts 
itself for a time, by a gradual rise, followed immediately by a gradual fall, and that 
once or twice the blood-pressure rose and fell in a jerky manner to a height of 15 or 
20 millims. (having previously stood at about 45 millims.). 
In the following experiment the attempt was made to prolong life by artificial respi- 
ration. 
Exp. XLIV.— March 31, 1874. 
Eabbit. — Weight 2075 grms. 
Dose 5 cub. centims. of the 5 per cent, solution (250 milligrammes 
V 2 0 5 ), injected under the skin. 
The kymograph was connected with the right carotid artery. 
The rabbit died within 22 minutes from the time of injection, artificial respiration 
being of no avail to prolong life. 
4 c 2 
