526 ME. J. PEIESTLEY ON THE PHYSIOLOGICAL ACTION OE VANADIUM. 
Exp. XLVI.— June 8, 1874. 
Rabbit. — Weight 2180 grms. 
Dose 1 cub. centim. of the 5 per cent, solution (50 milligrammes 
V 2 0 5 ), injected into the right external jugular vein. 
Time. 
Mean B. P. 
Pulse in 
10 seconds. 
Remarks. 
h. m. s. 
2 25 0 
Kymographic cannula inserted into left femoral artery; 
2 25 0 
100 
35-40 
cannula inserted into vein for injection. 
Normals prior to injection. The respiration-curves are 
2 30 0 
97 
35 
well shown. 
Commence to inject. Eespiration-curves well shown. 
2 30 15 
97) 
35 
A sudden rise of B. P. to the extent of 10 millims. here 
2 30 20 
106/ 
took place without any alteration of pulse or respiration- 
2 30 38 
70 
33 
curves. 
The B. P. now sank below the normal, and respiration- 
2 30 55 
72 
29 
curves disappeared. 
2 31 0 
11 
Injection complete. The character of the pulse changed 
2 31 45 
35 
11 
completely, becoming deeper, less regular, and less fre- 
quent. B. P. falling regularly. 
The pulse is very irregular, shallow, and long. 
2 32 40 
24 
12 
The pulse is so undecided and irregular as to render count- 
2 33 0 
ing difficult. 
A sudden and irregular rise in B. P. from 22 millims. to 
2 33 15 
24 
15 
30 millims., followed by a less sudden fall to 22 millims., 
occurred at this point. 
Pulse alternately long and short. Respiration 7-10 in 
2 34 15 
18 
13-14 
10 seconds and deep. 
Respiration slight; eye insensitive; heart-heats long, re- 
2 35 15 
12 
14 
gular, and dicrotic. 
Pulse long and very irregular. Rabbit has been strug- 
2 36 30 
10-5 
14 
gling. Respiration seems to have ceased. 
Respiration resumed in a series of gasps. 
2 38 30 
8 
Heart has ceased to beat ; death. 
In this experiment, in which vanadium was injected directly into a vein, the general 
symptoms are like those after injection under the skin, except that they supervene 
much more rapidly. Within 20 seconds after injection was commenced the blood- 
pressure rose rapidly from 97 to 106 millims., respiration-curves remaining normal. 
Within 38 seconds of the commencement of injection the blood-pressure had fallen 
below the normal, and respiration-curves were no longer to be seen, although the pulse 
was normal, except that it was slightly slower. From the time that injection was 
complete (1 minute after its commencement) the blood-pressure sank rapidly and 
almost constantly until the rabbit died, 7J minutes afterwards. During injection the 
pulse appeared normal but somewhat slower; but immediately after injection its 
characters changed very suddenly indeed, its rapidity sank from 29 to 11 in 10 seconds, 
and it became at first deep and regular, and afterwards slight and irregular. About 
5 minutes before death it picked up slightly. During the experiment the rabbit exhi- 
bited some struggles of a convulsive character, which were not, however, accompanied 
by any marked disturbance of blood-pressure. 
