ME. J. PEIESTLEY ON THE PHYSIOLOGICAL ACTION OE VANADIUM. 531 
rapidity, and afterwards in vigour, of the pulse, which developed first suddenly (from 
37 per 10 seconds to 26 per 10 seconds in the space of 15 seconds), but afterwards more 
gradually. 
Exp. LI. — June 23, 1874. 
Rabbit. — Weight 2465 grms. 
O O 
Dose *5 cub. centim. of the 5 per cent, solution (25 milligrammes 
V 2 0 5 ), injected into the right external jugular vein. 
Time. 
Mean B. P. 
Pulse in 
10 seconds. 
Eemarks. 
k. m. s. 
3 5 0 
Preparations as in Exp. L. 
•75 cub. centim. of a 1 per cent, solution of curare injected 
3 21 20 
109 
50 
into the vein. Artificial respiration commenced. 
3 22 22 
Commenced to divide cord. 
3 22 28 
160 
34 
Eise due to insertion of knife into cord. 
3 22 32 
Division of cord complete. 
3 22 35 
132. 
45 
Blood-pressure began to fall, but rose again (owing to irri- 
3 22 55 
146 
tation by bleeding ?) to 146 millims. 
3 25 30 
52 
40 
Blood-pressure again fell suddenly, and continued at 52 
3 27 0 
46 
26 
millims. 
The pulse began to get slower. 
3 27 20 
40 
The heart ceased to beat somewhat suddenly, and the blood- 
3 27 32 
25 
pressure sank to 25 millims. at once. 
3 28 0 
7-12 
The heart recommenced to beat with slow but vigorous con- 
3 28 30 
75 
30 
tractions, and quickly regained rapidity; the blood- 
pressure rose rapidly and exceeded, at first, its previous 
3 29 55 
48 
26 
level. 
The blood-pressure settled at last at about 48 millims. ; the 
3 30 23 
48 
26 
pulse did not regain its former rapidity. 
Commenced to inject the vanadate. 
3 30 35 
48 
23 
Injection complete. 
3 30 45 
48 
20 
The pulse became less frequent and the pressure sank 
3 30 55 
46 
14 
slightly. 
3 31 5 
The heart seemed to stop suddenly, and the blood-pressure 
3 31 20 
30 
at once sank to 30 millims. 
3 31 50 
8-13 
The heart began again just as it had done at 3 h 28 m , and 
3 32 5 
95 
23 
the pressure rose to 95 millims. 
3 32 10 
14 
The pulse again became slow, and the blood-pressnre fell to 
3 32 20 
65 
65 millims. 
3 32 30 
70 
20 
The pulse quickened a little, and the blood-pressure rose. 
3 33 10 
46 
Prom this point the blood-pressure sank qiute regularly 
until death supervened. The pulse became too faint to 
3 34 50 
22 
count. 
In this experiment the symptoms were complicated by a sudden and momentary 
stoppage of the heart’s action immediately after injection (at 3 h 31 m 5 s ), which is not, 
probably, to be attributed to the action of vanadium, as an exactly similar stoppage had 
taken place before injection (at 3 h 27 m 20 s ). With this exception the symptoms resemble 
those of the preceding experiment. 
4 D 2 
