532 MR. J. PRIESTLEY ON THE PHYSIOLOGICAL ACTION OE VANADIUM. 
Exp. LIL— July 1, 1874. 
Rabbit. — Weight 1810 grms. 
Dose *75 cub. centim. of the 5 per cent, solution (37'5 milligrammes 
V 2 0 5 ), injected into the right external jugular vein. 
Time. 
Mean. B. P. 
Pulse in 
10 seconds. 
Remarks. 
h. m. s. 
3 44 0 
96 
45 
Preparation as in Exp. L., without the loss of any blood. 
Pulse regular ; respiration-curves are well shown. 
3 46 30 
42 
•75 cub. centim. of a 1 per cent, solution of curare injected 
3 49 30 
102 
42 
into the vein. 
Artificial respiration commenced ; pulse stronger. 
3 56 0 
46 
More curare injected. 
4 0 0 
On raising head to divide cord the blood-pressure rose and 
4 10 
110 
fell several times. 
Rise due to insertion of knife into cord. 
4 1 20 
124 
Cord divided : blood-pressure first rose and then fell, until 
4 6 0 
36 
30-33 
it stood steadily at 36 millimetres. Pulse of normal 
4 12 30 
34 
30 
depth. 
Injection of vanadate commenced. About 5 seconds after 
4 12 50 
71 
28 
commencement the blood-pressure began to rise, and 
reached 71 millimetres by the time injection was com- 
4 13 10 
64 
27 
pleted. 
Blood-pressure fell gradually, the pulse becoming less fre- 
4 13 30 
54 
26 
quent and fainter. 
4 13 50 
62 
24 
Blood-pressure rose gradually, the pulse still sinking in 
4 14 0 
60 
24 
rapidity and becoming fainter. 
Blood-pressure declined again, and continued to do so until 
4 14 30 
48 
the death of the rabbit, the pulse becoming too faint to 
4 15 0 
30 
he counted. 
Death. 
The symptoms of this experiment resemble in general those of Exp. L. Injection of 
the poison caused a gradual rise of blood-pressure, followed in succession by a fall, 
another rise, and another fall, which continued until the death of the rabbit. The pulse 
became gradually slower and fainter from the moment of injection. 
In the following experiment the object was to observe directly the action of vanadium 
upon the heart after its introduction into the circulation. In order to do this, all the 
extracardiac circulatory nervous centres were removed in a frog by division of the cord 
below the atlanto-occipital articulation and destruction of the nervous organs above ; and 
the heart was then fully exposed to view. 
