536 ME. J. PEIESTLET ON THE PHYSIOLOGICAL ACTION OE VANADIUM. 
experiment proceeded with. G is the electro-magnetic pen connected with Ludwig’s 
Stromunterhrecher. 
Both injection under the skin and injection into veins were made use of. 
Exp. LIY.— May 6, 1874. 
Rabbit. — Weight 1760 grms. 
Dose* about 5 cub. centims. of the 5 per cent, solution (250 milli- 
grammes V 2 0 5 ), injected under the skin. 
Time. 
Respirations 
in 10 seconds. 
Remarks. 
h. m. s. 
12 15 0 
Tracheotomy : insertion of glass cannula into trachea. 
12 18 0 
io 
Normal prior to injection. 
12 19 0 
10 
Do. do. 
12 22 40 
ii 
Injection commenced. 
12 26 30 
12 
12 27 0 
Injection complete. 
12 29 0 
ii 
12 30 0 
12-5 
12 33 0 
15 
12 35 0 
17 
Eespiration shallow. 
12 40 0 
23 
Do. very shallow. 
12 42 0 
22 
Do. do. 
12 44 20 
17 
Do. do. 
12 46 0 
20 
Do. do. 
12 50 0 
16 
Still shallower than before. 
12 52 0 
13 
Eespiration deeper and less regular. 
12 55 0 
10 
1 0 30 
17 
Very shallow. 
1 4 30 
15 
Do. 
19 0 
13 
Do. Eye sensitive. 
1 14 30 
13 
Do. 
1 20 0 
11 
Do. 
1 23 0 
3 
Gasps. Short, shallow inspirations, followed by longer exspirations. 
Eye insensitive. Twitching of abdominal muscles. Pupil dilated. 
Dead. 
A post mortem examination made at l h 30 m showed that the right and left auricles 
were beating, that the ventricles also were irritable, and that the right side of the heart 
was much distended. 
From this experiment we learn that injection of vanadate of sodium under the skin 
causes increase of rapidity, and diminution of depth, of respiration ; that the symptoms 
commenced to develop almost immediately after injection, and had become most 
marked 20 minutes after injection ; that the symptoms abated somewhat, but afterwards 
became violent again ; and that death was accompanied, if not immediately caused, by 
asphyxia. 
* A little of the solution was lost during injection. 
