538 MB. J. PEIESTLET ON THE PHYSIOLOGICAL ACTION OF VANADIUM. 
Exp. EVIL— May 19, 1874. 
Rabbit. — Weight 1347 grms. 
Dose 5 cub. centims. of the 5 per cent, solution (250 milligrammes 
V 2 0 5 ), injected under the skin. 
The rabbit died within 15 minutes after injection. 
This experiment agrees with the preceding, except that the symptoms came on with 
remarkable rapidity ; possibly the injection-syringe punctured some considerable vein 
(see the experiments on direct injection). 
In the following two experiments injection took place directly into a vein. 
Exp. LVIII.— June 15, 1874. 
Rabbit. — Weight 2430 grms. 
Dose 1 cub. centim. of the 5 per cent, solution (50 milligrammes 
V 2 0 5 ), injected into the right external jugular vein. 
Time. 
Respirations 
in 10 seconds. 
Remarks. 
h. m. s. 
Tracheotomy. Insertion of glass cannula into trachea ; exposure of 
carotid artery for simultaneous blood-pressure tracing. Insertion 
of cannula into vein for injection. 
12 13 0 
10 
Normal prior to injection. 
12 15 0 
9 
Injection commenced. Respiration not so deep. 
12 15 15 
17 
Injection finished. Respiration very shallow indeed. 
12 15 30 
39 
Extremely shallow. 
12 16 15 
12 
Rabbit commenced to struggle, rendering respiration irregular and 
deeper. 
About normal depth. 
12 16 30 
12 
Rather shallower. 
12 18 45 
9 
Very irregular in depth, owing to the almost incessant and violent 
12 19 0 
struggles of the rabbit. Convulsions and tonic spasms of the lower 
limbs. 
Eye insensitive ; pupil largely dilated. 
12 20 0 
3 
A succession of shallow gasps. Dead. 
The cord and brain were exposed the whole length, and appeared to be quite normal. 
In this experiment the general symptoms were the same as in the case of hypodermic 
injection, except that they were much more rapid. Within 15 seconds of the com- 
mencement of injection respiration was becoming much more rapid and shallow, and the 
maximum of rapidity and shallowness was attained within 30 seconds of the commence- 
ment. From this point respiration declined until death, which occurred amid a 
succession of gasps. 
