MB. J. PRIESTLEY ON THE PHYSIOLOGICAL ACTION OE VANADIUM. 539 
Exp. LIX. — June 15, 1874. 
Eabbit. — Weight 1184 grms. 
Dose 1 cub. centim.* of the 5 per cent, solution (250 milligrammes 
V 2 0 5 ), injected into the right external jugular vein. 
The rabbit died within 4 minutes 45 seconds after injection. 
The symptoms in this case were substantially the same as in the preceding expe- 
riment. 
In the next experiment an attempt was made to discover the effect of poisoning by 
vanadium upon respiration after section of the vagi. 
Exp. LX.— May 11, 1874. 
Eabbit. — Weight 1235 grms. 
Dose 5 cub. centims. of the 5 per cent, solution (250 milligrammes 
V 2 0 5 ), injected under the skin. 
Time. 
Eespirations 
in 10 seconds. 
Remarks. 
h. m. s. 
Nervi vagi exposed. Tracheotomy. Insertion of glass cannula into 
the trachea. 
2 45 0 
8-10 
Normal respirations, somewhat irregular. 
2 51 0 
Vagi divided. 
2 53 30 
6-7 
Respirations after section of vagi deeper than before. Struggles of 
2 56 0 
rabbit. 
Injection commenced. 
2 57 15 
Injection complete. 
2 58 0 
8 
Rather shallower. 
3 0 0 
6-7 
Slightly deeper, j 
3 0 30 
8 
Slightly deeper. 1 Struggles of rabbit. 
3 10 
9-10 
Rather deeper. J 
3 2 0 
9 
Much shallower. 
3 3 0 
3-5 
Very irregular and more like gasps. 
3 5 0 
Short, sharp gasps at long intervals. 
3 7 0 
Pupil insensitive and much dilated. 
Dead. 
In this experiment the injection of vanadate of sodium beneath the skin of a rabbit 
whose vagi had been divided previously caused a distinct shallowness and increase in 
rapidity of respiration, as in the case of rabbits whose vagi were intact ; but the altera- 
tions were not, proportionally, so great in the former as in the latter case. 
'Resume of the Action of Vanadium upon Respiration. 
From the experiments just detailed we learn that the action of vanadium, in the form 
of sodium vanadate, upon respiration is to cause coincidently increased rapidity and 
diminished depth, which proceed regularly until the period of the greatest intensity of 
* A small quantity escaped during injection. 
4 e 2 
