ME. J. PKIESTLEY ON THE PHYSIOLOGICAL ACTION OF VANADIUM. 543 
The battery consisted of one Leclanche s element. Currents interrupted. 
This experiment (a modification of the preceding) practically confirms the results 
previously obtained, the difference in irritability between the two frogs being merely 
such as might be due to differences in idiosyncracy, or due to the deficient aeration of 
the blood in frog (a), owing to early cessation of respiration, and not such as ought to 
be attributed to a direct action of the poison on muscle or nerve. 
Exp. LXVI.— May 25, 1874. 
Guineapig (a). — Weight 310 grms. 
Dose 3 cub. centims. of the 5 per cent, solution (150 milli- 
grammes V 2 0 5 ), injected under the skin. 
Guineapig (0). — Weight 400 grms. 
Time. 
Guineapig (a). 
Guineapig (/ 3 ). 
h. m. 
4 20 
4 25 
4 26 
4 28 
4 29 
4 35 
Injection complete. Euns about basket. 
Lies on side. Eyeballs sensitive. 
Convulsions of hind legs. 
Clonic spasms. Moves on pinching. 
Gasps and retches ; passes urine. Eyeball 
insensitive. Dead. 
Gasped. 
Cord exposed; electrodes inserted. Very slight 
movements of dorsal muscles with the 
secondary coil at 0. 
The sciatic nerve and the muscles gave good 
contractions on stimulation. 
Bled to death [guineapig (a) was not bled]. 
Cord exposed ; electrodes inserted. Active 
movements of dorsal muscles with secondary 
coil at 8-10. 
The sciatic nerve and the muscles gave good 
contractions on stimulation. 
A battery of one Leclanche’s element was used. Currents interrupted. 
This experiment loses value from the circumstance that one animal was bled while 
the other was not. As regards the (sciatic) nerves and muscles, it confirms the experi- 
ments on frogs ; but, as regards the cord, it seems to show that poisoning by vanadium 
interferes with the conductivity of the cord. But this observation, in the case of a warm- 
blooded animal, must be regarded as having little weight when it opposes observations 
to the contrary effect in experiments on cold-blooded animals. 
Exp. LXVII.— May 26, 1874. 
Eabbit (a ). — Weight 900 grms. 
Dose 2 cub. centims. of the 5 per cent, solution (100 milligrammes 
V 2 0 5 ), injected under the skin. 
Eabbit (0). — Weight 890 grms. 
